NP_036387.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
5'-3' exoribonuclease 2
NCBI Official Synonym Full Names
5'-3' exoribonuclease 2
NCBI Protein Information
5'-3' exoribonuclease 2
UniProt Protein Name
5'-3' exoribonuclease 2
UniProt Synonym Protein Names
DHM1-like protein; DHP protein
UniProt Synonym Gene Names
UniProt Entry Name
XRN2_HUMAN
NCBI Summary for XRN2
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for XRN2
XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Nucleolus; RNA-binding; Ribonuclease; RNA processing; EC 3.1.13.-
Chromosomal Location of Human Ortholog: 20p11.2-p11.1
Cellular Component: membrane; nucleolus; nucleus
Molecular Function: 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; zinc ion binding
Biological Process: RNA processing; regulation of transcription, DNA-dependent; RNA metabolic process; RNA catabolic process; spermatogenesis; DNA catabolic process, exonucleolytic; cell growth; mRNA processing; transcription termination
Product References and Citations for anti-XRN2 antibody
Lu, Y., et al. Oncogene 29(7):1041-1049(2010) Yang, X.C., et al. Mol. Cell. Biol. 29(1):31-42(2009) Kaneko, S., et al. Genes Dev. 21(14):1779-1789(2007) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) Olsen, J.V., et al. Cell 127(3):635-648(2006)
Research Articles on XRN2
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Products associated with anti-XRN2 antibody
Pathways associated with anti-XRN2 antibody
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Diseases associated with anti-XRN2 antibody
Organs/Tissues associated with anti-XRN2 antibody
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