NP_004631.1
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NCBI Related Accession #
Human (Predicted Reactivity: Mouse, Rat, Bovine, Chicken, Drosophila, Pig) NP_542165.1[Other Products]
NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
spliceosome RNA helicase DDX39B
NCBI Official Synonym Full Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
NCBI Protein Information
spliceosome RNA helicase DDX39B
UniProt Protein Name
Spliceosome RNA helicase DDX39B
UniProt Synonym Protein Names
56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; DEAD box protein UAP56; HLA-B-associated transcript 1 protein
UniProt Synonym Gene Names
UniProt Entry Name
DX39B_HUMAN
NCBI Summary for DDX39B
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]
UniProt Comments for DDX39B
BAT1: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the DEAD box helicase family. DECD subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.13; Spliceosome; RNA-binding; RNA splicing; Helicase
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: nucleoplasm; spliceosome; cytoplasm; nuclear speck; nucleus
Molecular Function: ATP-dependent protein binding; U4 snRNA binding; protein binding; RNA-dependent ATPase activity; ATP binding; ATP-dependent RNA helicase activity; U6 snRNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; positive regulation of RNA elongation; RNA splicing; RNA secondary structure unwinding; spliceosome assembly; intronless viral mRNA export from host nucleus
Product References and Citations for anti-DDX39B antibody
Choudhary C., et.al., Science 325:834-840(2009). Boyne J.R., et.al., PLoS Pathog. 4:E1000194-E1000194(2008).
Research Articles on DDX39B
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Pathways associated with anti-DDX39B antibody
Diseases associated with anti-DDX39B antibody
Organs/Tissues associated with anti-DDX39B antibody
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