Q86UU9.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,680 Da
NCBI Official Full Name
Tachykinin-4
NCBI Official Synonym Full Names
tachykinin 4 (hemokinin)
NCBI Protein Information
tachykinin-4
UniProt Protein Name
Tachykinin-4
UniProt Synonym Protein Names
Preprotachykinin-C; PPT-C
UniProt Synonym Gene Names
UniProt Entry Name
TKN4_HUMAN
NCBI Summary for TAC4 (HGNC:16641)
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TAC4 (HGNC:16641)
TAC4: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. Belongs to the tachykinin family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: extracellular space
Molecular Function: receptor binding
Biological Process: cell-cell signaling; elevation of cytosolic calcium ion concentration; inflammatory response; tachykinin signaling pathway
Research Articles on TAC4 (HGNC:16641)
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Pathways associated with TAC4 (HGNC:16641) blocking peptide
Diseases associated with TAC4 (HGNC:16641) blocking peptide
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