Q9BSW2.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,193 Da
NCBI Official Full Name
EF-hand calcium-binding domain-containing protein 4B
NCBI Official Synonym Full Names
calcium release activated channel regulator 2A
NCBI Official Synonym Symbols
NCBI Protein Information
EF-hand calcium-binding domain-containing protein 4B
UniProt Protein Name
EF-hand calcium-binding domain-containing protein 4B
UniProt Synonym Protein Names
Calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; Calcium release-activated channel regulator 2A
UniProt Synonym Gene Names
UniProt Entry Name
EFC4B_HUMAN
UniProt Comments for CRACR2A
EFCAB4B: Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Belongs to the EFCAB4 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 12p13.32
Cellular Component: cytoplasm; Golgi apparatus; membrane; nucleolus; nucleus
Molecular Function: calcium ion binding; protein binding
Biological Process: activation of store-operated calcium channel activity; positive regulation of calcium ion transport
Research Articles on CRACR2A
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Diseases associated with CRACR2A blocking peptide
Organs/Tissues associated with CRACR2A blocking peptide
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