P47211.3
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,953 Da
NCBI Official Full Name
Galanin receptor type 1
NCBI Official Synonym Full Names
galanin receptor 1
NCBI Protein Information
galanin receptor type 1
UniProt Protein Name
Galanin receptor type 1
UniProt Synonym Gene Names
UniProt Entry Name
GALR1_HUMAN
NCBI Summary for GALR1
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
UniProt Comments for GALR1
GALR1: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: galanin receptor activity; peptide hormone binding; protein binding
Biological Process: digestion; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of cortisol secretion; positive regulation of transcription from RNA polymerase II promoter
Research Articles on GALR1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with GALR1 blocking peptide
Diseases associated with GALR1 blocking peptide
Organs/Tissues associated with GALR1 blocking peptide
|