NP_035463.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
C-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 2
NCBI Official Synonym Symbols
JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF; AI323594 [Similar Products]
NCBI Protein Information
C-C motif chemokine 2
UniProt Protein Name
C-C motif chemokine 2
UniProt Synonym Protein Names
Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Platelet-derived growth factor-inducible protein JE; Small-inducible cytokine A2
UniProt Synonym Gene Names
UniProt Entry Name
CCL2_MOUSE
NCBI Summary for Ccl2
This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]
UniProt Comments for Ccl2
CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis
Cellular Component: cell soma; cytoplasm; dendrite; endocytic vesicle; extracellular region; extracellular space; nerve terminal; perikaryon; perinuclear region of cytoplasm; rough endoplasmic reticulum; synapse
Molecular Function: CCR2 chemokine receptor binding; chemokine activity; cytokine activity; G-protein-coupled receptor binding; heparin binding; protein binding
Biological Process: angiogenesis; cellular calcium ion homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; glial cell migration; immune response; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; macrophage chemotaxis; monocyte chemotaxis; negative regulation of angiogenesis; neutrophil chemotaxis; positive regulation of cell adhesion; positive regulation of cell-cell adhesion; positive regulation of cellular extravasation; positive regulation of collagen biosynthetic process; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of leukocyte mediated cytotoxicity; positive regulation of leukocyte migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of synaptic transmission; positive regulation of T cell activation; positive regulation of tumor necrosis factor production; regulation of cell shape; response to heat; response to wounding; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Research Articles on Ccl2
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Products associated with anti-Ccl2 antibody
Pathways associated with anti-Ccl2 antibody
Diseases associated with anti-Ccl2 antibody
Organs/Tissues associated with anti-Ccl2 antibody
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