NP_077324.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,119 Da
NCBI Official Full Name
dynactin subunit 3 isoform 2
NCBI Official Synonym Full Names
dynactin 3 (p22)
NCBI Protein Information
dynactin subunit 3; p22; dynactin light chain; dynactin 3, isoform 1; dynactin complex subunit 22 kDa subunit
UniProt Protein Name
Dynactin subunit 3
UniProt Synonym Protein Names
Dynactin complex subunit 22 kDa subunit
UniProt Synonym Gene Names
UniProt Entry Name
DCTN3_HUMAN
NCBI Summary for DCTN3
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for DCTN3
dynactin 3: Together with dynein may be involved in spindle assembly and cytokinesis. Belongs to the dynactin subunit 3 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: centrosome; dynactin complex; perinuclear region of cytoplasm; spindle; midbody; cytosol; cleavage furrow
Molecular Function: protein binding; structural molecule activity
Biological Process: mitosis; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytokinesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based process
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Pathways associated with DCTN3 elisa kit
Diseases associated with DCTN3 elisa kit
Organs/Tissues associated with DCTN3 elisa kit
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