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anti-DEPDC5 antibody :: DEPDC5 Antibody

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Catalog # MBS8502990
Unit / Price
  0.2 mL  /  $330 +1 FREE 8GB USB
Product Name

DEPDC5, Antibody

Popular Item
Also Known As

DEPDC5 Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2397
OMIM
604364
Species Reactivity
Human
Predicted : Rat, Mouse. Not yet tested in other species.
Form/Format
Rabbit anti-DEPDC5 antibody purified by protein A column containing 0.02% NaN3
Host Note
Rabbit polyclonal DEPDC5 (1) antibody was raised against a recombinate human DEPDC5 protein 129aa-332aa
Preparation and Storage
Already reconstituted in 200 ul sterile H2O. The antibody is stable for at least one year when stored at -20°C after reconstitution.
Other Notes
Small volumes of anti-DEPDC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DEPDC5 antibody
For research use only.
Application Notes for anti-DEPDC5 antibody
ELISA 1:20,000-80,000
Western blot analysis 1:200-1:1000
Immunohistochemistry 1:100-1:500

Optimal dilutions/concentrations should be determined by end user.

Testing Data of anti-DEPDC5 antibody
anti-DEPDC5 antibody Testing Data image
Testing Data #2 of anti-DEPDC5 antibody
anti-DEPDC5 antibody Testing Data #2 image
NCBI/Uniprot data below describe general gene information for DEPDC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens DEP domain containing 5, mRNA
NCBI Official Synonym Full Names
DEP domain containing 5
NCBI Official Symbol
DEPDC5  [Similar Products]
NCBI Official Synonym Symbols
DEP.5; FFEVF; FFEVF1
  [Similar Products]
NCBI Protein Information
GATOR complex protein DEPDC5
UniProt Protein Name
GATOR complex protein DEPDC5
UniProt Synonym Protein Names
DEP domain-containing protein 5
UniProt Gene Name
DEPDC5  [Similar Products]
NCBI Summary for DEPDC5
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for DEPDC5
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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