BC015234
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,044 Da
NCBI Official Full Name
Homo sapiens diacylglycerol O-acyltransferase homolog 2 (mouse), mRNA
NCBI Official Synonym Full Names
diacylglycerol O-acyltransferase 2
NCBI Protein Information
diacylglycerol O-acyltransferase 2
UniProt Protein Name
Diacylglycerol O-acyltransferase 2
UniProt Synonym Protein Names
Acyl-CoA retinol O-fatty-acyltransferase (EC:2.3.1.76); ARAT; Retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2
UniProt Synonym Gene Names
UniProt Entry Name
DGAT2_HUMAN
NCBI Summary for DGAT2
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for DGAT2
DGAT2: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT). Belongs to the diacylglycerol acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.3.1.20; Transferase; Membrane protein, integral; Lipid Metabolism - glycerolipid; Membrane protein, multi-pass; EC 2.3.1.76; Cofactor and Vitamin Metabolism - retinol
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to membrane; lipid particle; mitochondrion; perinuclear region of cytoplasm
Molecular Function: diacylglycerol O-acyltransferase activity; protein homodimerization activity
Biological Process: cholesterol homeostasis; diacylglycerol metabolic process; fatty acid homeostasis; sequestering of lipid; triacylglycerol biosynthetic process
Research Articles on DGAT2
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Pathways associated with DGAT2 cdna clone
Diseases associated with DGAT2 cdna clone
Organs/Tissues associated with DGAT2 cdna clone
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