NP_001182572.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,620 Da
NCBI Official Full Name
dihydrofolate reductase, mitochondrial
NCBI Official Synonym Full Names
dihydrofolate reductase-like 1
NCBI Official Synonym Symbols
NCBI Protein Information
dihydrofolate reductase, mitochondrial; dihydrofolate reductase pseudogene 4; dihydrofolate reductase-like protein 1
UniProt Protein Name
Dihydrofolate reductase, mitochondrial
UniProt Synonym Protein Names
Dihydrofolate reductase-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
DYRL1_HUMAN
UniProt Comments for DHFRL1
DHFRL1: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. Belongs to the dihydrofolate reductase family.
Protein type: Mitochondrial; EC 1.5.1.3
Chromosomal Location of Human Ortholog: 3q11.1
Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane
Molecular Function: mRNA binding; dihydrofolate reductase activity; NADP binding
Biological Process: tetrahydrofolate metabolic process; tetrahydrofolate biosynthetic process; nucleotide biosynthetic process; one-carbon compound metabolic process; glycine biosynthetic process; thymidine biosynthetic process
Research Articles on DHFRL1
Precautions
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Disclaimer
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Pathways associated with DHFRL1 elisa kit
Organs/Tissues associated with DHFRL1 elisa kit
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