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DIABLO recombinant protein :: Diablo homolog, mitochondrial (DIABLO) Recombinant Protein

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Catalog # MBS1297904
Unit / Price
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  0.05 mg (E-Coli)  /  $580 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $715 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $780 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $860 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $955 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $975 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,095 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,190 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,290 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,365 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,740 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,790 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,940 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,785 +3 FREE 8GB USB
DIABLO recombinant protein
Product Name

Diablo homolog, mitochondrial (DIABLO), Recombinant Protein

Full Product Name

Recombinant Human Diablo homolog, mitochondrial (DIABLO)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
56-239aa, Full Length of Mature Protein
Sequence
AVPIAQKSEP HSLSSEALMR RAVSLVTDST STFLSQTTYA LIEAITEYTK AVYTLTSLYR QYTSLLGKMN SEEEDEVWQV IIGARAEMTS KHQEYLKLET TWMTAVGLSE MAAEAAYQTG ADQASITARN HIQLVKLQVE EVHQLSRKAE TKLAEAQIEE LRQKTQEEGE ERAESEQEAY LRED
OMIM
605219
3D Structure
ModBase 3D Structure for Q9NR28
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DIABLO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DIABLO recombinant protein
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
NCBI/Uniprot data below describe general gene information for DIABLO. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,284 Da
NCBI Official Full Name
diablo homolog, mitochondrial isoform 4
NCBI Official Synonym Full Names
diablo IAP-binding mitochondrial protein
NCBI Official Symbol
DIABLO  [Similar Products]
NCBI Official Synonym Symbols
SMAC; DFNA64
  [Similar Products]
NCBI Protein Information
diablo homolog, mitochondrial
UniProt Protein Name
Diablo homolog, mitochondrial
UniProt Synonym Protein Names
Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac
Protein Family
UniProt Gene Name
DIABLO  [Similar Products]
UniProt Synonym Gene Names
SMAC; Smac  [Similar Products]
NCBI Summary for DIABLO
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
UniProt Comments for DIABLO
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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