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DIAPH3 cdna clone

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Catalog # MBS1272865
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
DIAPH3 cdna clone
Product Name

DIAPH3, cDNA Clone

Popular Item
Full Product Name

DIAPH3 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1272865 Technical Datasheet
Sequence
atgagtgagg agaggagcct ttccttattg gccaaagccg tggatcccag acaccccaat atgatgacag atgtggttaa acttctctct gcggtatgca ttgtagggga agaaagcatc cttgaagaag ttttagaagc tttaacttca gctggtgaag aaaaaaaaat tgacagattt ttttgtattg tggaaggcct ccggcacaat tcagttcaac tgcaagtagc ttgtatgcag ctcatcaatg ccctggttac atctcctgat gatttggatt tcaggcttca catcagaaat gaatttatgc gttgtggatt gaaagagata ttgccaaatt taaaatgcat taagaatgat ggcctggata tccaacttaa agtctttgat gagcataaag aagaagattt gtttgagtta tcccatcgcc ttgaagatat tagagctgaa cttgatgaag catatgatgt ttacaacatg gtgtggagca cagttaaaga aactagagca gagggatatt ttatttctat tcttcagcat cttttgctga ttcgaaatga ttattttata aggcaacaat acttcaaatt aattgatgag tgtgtatccc agattgtatt gcatagagat ggaatggatc cagacttcac atatcgaaaa agactagatt tagatttaac ccagtttgta gacatttgca tagatcaagc aaaactagaa gagtttgaag agaaagcatc agaactttac aagaaatttg aaaaagagtt taccgaccac caagaaactc aggctgaatt gcagaaaaaa gaggcaaaga ttaatgagct tcaagcagag ctacaagctt ttaagtctca gtttggtgcc ttgccagctg attgtaatat tcctttgcct ccctctaaag aaggtggaac tggccactca gcacttcctc ctccgcctcc actgccttct ggtggagggg tgccgcctcc acctcctccc ccaccacctc ctccacttcc aggaatgcgg atgccattca gtggtcctgt gcctccacca cctcccctgg gattccttgg aggacaaaat tctcctcctc taccaatcct gccatttggg ttgaaaccaa agaaagaatt taaacctgaa atcagcatga gaagattgaa ttggttaaag atcagacctc atgaaatgac tgaaaactgt ttctggataa aagtaaatga aaataagtat gaaaacgtgg atttgctttg taaacttgag aatacatttt gttgccaaca aaaagagaga agagaagagg aagatattga agagaagaaa tcgattaaga aaaaaattaa agaacttaag tttttagatt ctaaaattgc ccagaacctt tcaatcttcc tgagctcttt tcgggtgcca tatgaggaaa tcagaatgat gatattggaa gtagatgaaa cacggttggc agagtctatg attcagaact taataaagca tcttcctgat caagagcaat taaattcatt gtctcagttc aagagtgaat atagcaactt atgtgaacct gagcagtttg tggttgtgat gagcaatgtg aagagactac ggccacggct cagtgctatt ctctttaagc ttcagtttga agagcaggtg aacaacatca aacctgacat catggctgtc agtactgcct gcgaagagat aaagaagagc aaaagcttta gcaagttgct ggaacttgta ttgctaatgg gaaactacat gaatgctggc tcccggaatg ctcaaacctt cggatttaac cttagctctc tctgtaaact aaaggacaca aaatcagcag atcagaaaac aacgctactt catttcctgg tagaaatatg tgaagagaag taccctgata tactgaattt tgtggatgat ttggaacctt tagacaaagc tagtaaagtc tctgtagaaa cgctggaaaa gaatttgagg cagatgggaa ggcagcttca acagcttgag aaggaattgg aaacctttcc ccctcctgag gacttgcatg acaagtttgt gacaaagatg tccagatttg ttatcagtgc aaaagaacaa tatgagacac tttcgaagtt acacgaaaac atggaaaagt tataccagag tataatagga tactatgcca ttgatgtgaa gaaggtgtct gtggaagact ttcttactga cctgaataac ttcagaacca cattcatgca agcaataaag gagaatatca aaaaaagaga agcagaggaa aaagaaaaac gtgtcagaat agctaaagaa ttagcagagc gagaaagact cgaacgccaa caaaagaaaa agcgtttatt agaaatgaag actgagggtg atgagacagg agtgatggat aatctgctgg aggccttgca gtccggggct gccttccgcg acagaagaaa aaggacaccg atgccaaaag atgttcggca gagtctcagt ccaatgtctc agaggcctgt tctgaaagtt tgtaaccatg gtaataaacc gtatttataa
OMIM
609129
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DIAPH3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DIAPH3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
127,856 Da
NCBI Official Full Name
Homo sapiens diaphanous homolog 3 (Drosophila), mRNA
NCBI Official Synonym Full Names
diaphanous related formin 3
NCBI Official Symbol
DIAPH3  [Similar Products]
NCBI Official Synonym Symbols
AN; DIA2; DRF3; AUNA1; NSDAN; diap3; mDia2
  [Similar Products]
NCBI Protein Information
protein diaphanous homolog 3
UniProt Protein Name
Protein diaphanous homolog 3
UniProt Synonym Protein Names
Diaphanous-related formin-3; DRF3; MDia2
Protein Family
UniProt Gene Name
DIAPH3  [Similar Products]
UniProt Synonym Gene Names
DIAP3; DRF3  [Similar Products]
UniProt Entry Name
DIAP3_HUMAN
NCBI Summary for DIAPH3
This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Comments for DIAPH3
Diaphanous-3: Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Defects in DIAPH3 are the cause of auditory neuropathy, autosomal dominant, type 1 (AUNA1). A form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem. A disease- causing mutation in the conserved 5'-UTR leads to increased protein expression (PubMed:20624953). Belongs to the formin homology family. Diaphanous subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q21.2

Cellular Component: cell-cell adherens junction; cytosol

Disease: Auditory Neuropathy, Autosomal Dominant, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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