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Dkc1 recombinant protein :: H/ACA ribonucleoprotein complex subunit 4 (Dkc1) Recombinant Protein

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Catalog # MBS1454122
Unit / Price
  0.05 mg (E-Coli)  /  $930 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $985 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,220 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,245 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,460 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,520 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,765 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,085 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,290 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,360 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,410 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,525 +4 FREE 8GB USB
Dkc1 recombinant protein
Product Name

H/ACA ribonucleoprotein complex subunit 4 (Dkc1), Recombinant Protein

Full Product Name

Recombinant Mouse H/ACA ribonucleoprotein complex subunit 4 (Dkc1)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-509aa, Full Length of Mature Protein
Sequence
ADAEVITFPK KHKKKKDRKP LQEDDVAEIQ HAEEFLIKPE SKVAQLDTSQ WPLLLKNFDK LNVRTAHYTP LPCGSNPLKR EIGDYIRTGF INLDKPSNPS SHEVVAWIRR ILRVEKTGHS GTLDPKVTGC LIVCIERATR LVKSQQSAGK EYVGIVRLHN AIEGGTQLSR ALETLTGALF QRPPLIAAVK RQLRVRTIYE SKMIEYDPER RLGIFWVSCE AGTYIRTLCV HLGLLLGVGG QMQELRRVRS GVMSEKDHMV TMHDVLDAQW LYDNHKDESY LRRVVYPLEK LLTSHKRLVM KDSAVNAICY GAKIMLPGLL RYEDGIEVNQ EIVVITTKGE AICMAIALMT TAVISTCDHG IVAKIKRVIM ERDTYPRKWG LGPKASQKKM MIKQGLLDKH GKPTDNTPAT WKQDYIDYSD SGKNTLVTEA VQAPQLAAEA VNVIKRKRDS ESESDETPTV PQLKEKKKKK DKKPKTVLES GGETGDGDND TTKKKKKKKV KVVEEMSE
3D Structure
ModBase 3D Structure for Q9ESX5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Dkc1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Dkc1 recombinant protein
This gene is a member of the H
ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C
D and H
ACA. The H
ACA snoRNPs also include the NOLA1, 2 and 3 proteins. This protein and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H
ACA snoRNP proteins are also components of the telomerase complex. This protein is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Dkc1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,402 Da
NCBI Official Full Name
H/ACA ribonucleoprotein complex subunit 4 isoform 3
NCBI Official Synonym Full Names
dyskeratosis congenita 1, dyskerin
NCBI Official Symbol
NCBI Official Synonym Symbols
BC068171
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NCBI Protein Information
H/ACA ribonucleoprotein complex subunit 4
UniProt Protein Name
H/ACA ribonucleoprotein complex subunit 4
UniProt Synonym Protein Names
Dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein NAP57; Nucleolar protein family A member 4; snoRNP protein DKC1
UniProt Gene Name
UniProt Comments for Dkc1
Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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