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Dld recombinant protein :: Dihydrolipoyl dehydrogenase, mitochondrial (Dld) Recombinant Protein

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Catalog # MBS1245710
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $895 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $960 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,190 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,195 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,300 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,320 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,435 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,475 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,725 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,000 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,235 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,315 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,340 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,450 +4 FREE 8GB USB
Dld recombinant protein
Product Name

Dihydrolipoyl dehydrogenase, mitochondrial (Dld), Recombinant Protein

Full Product Name

Recombinant Mouse Dihydrolipoyl dehydrogenase, mitochondrial (Dld)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
36-509aa, Full Length of Mature Protein
Sequence
ADQPIEADVT VIGSGPGGYV AAIKSAQLGF KTVCIEKNET LGGTCLNVGC IPSKALLNNS HYYHMAHGKD FASRGIEIPE VRLNLEKMME QKHSAVKALT GGIAHLFKQN KVVHVNGFGK ITGKNQVTAT KADGSTQVID TKNILVATGS EVTPFPGITI DEDTIVSSTG ALSLKKVPEK LVVIGAGVIG VELGSVWQRL GADVTAVEFL GHVGGIGIDM EISKNFQRIL QRQGFKFKLN TKVTGATKKS DGKIDVSVEA ASGGKAEVIT CDVLLVCIGR RPFTQNLGLE ELGIELDPKG RIPVNNRFQT KIPNIYAIGD VVAGPMLAHK AEDEGIICVE GMAGGAVHID YNCVPSVIYT HPEVAWVGKS EEQLKEEGIE FKIGKFPFAA NSRAKTNADT DGMVKILGHK STDRVLGAHI LGPGAGEMVN EAALALEYGA SCEDIARVCH AHPTLSEAFR EANLAAAFGK PINF
3D Structure
ModBase 3D Structure for O08749
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Dld recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Dld recombinant protein
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
NCBI/Uniprot data below describe general gene information for Dld. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,272 Da
NCBI Official Full Name
dihydrolipoyl dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
dihydrolipoamide dehydrogenase
NCBI Official Symbol
NCBI Protein Information
dihydrolipoyl dehydrogenase, mitochondrial
UniProt Protein Name
Dihydrolipoyl dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Dihydrolipoamide dehydrogenase
Protein Family
UniProt Gene Name
NCBI Summary for Dld
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]
UniProt Comments for Dld
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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