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DNAH5 elisa kit :: Human dynein, axonemal, heavy chain 5 ELISA Kit

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Catalog # MBS9337198
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DNAH5 elisa kit
Product Name

dynein, axonemal, heavy chain 5 (DNAH5), ELISA Kit

Popular Item
Full Product Name

Human Dynein heavy chain 5, axonemal, DNAH5 ELISA Kit

Product Synonym Names
Human Dynein heavy chain 5; axonemal (DNAH5) ELISA kit; CILD3; DNAHC5; FLJ46759; HL1; KIAA1603; KTGNR; PCD; axonemal beta dynein heavy chain 5; ciliary dynein heavy chain 5; dynein; axonemal; heavy polypeptide 5; dynein; axonemal; heavy chain 5
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 608644
3D Structure
ModBase 3D Structure for Q8TE73
Species Reactivity
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Samples
Body fluids, tissue homogenates, secretions or feces samples
Assay Type
Quantitative Sandwich
Detection Range
3.12 ng/ml - 100 ng/ml
Sensitivity
1.0 ng/ml.
Intra-assay Precision
Intra-assay CV (%) is less than 15%
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of DNAH5 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for DNAH5purchase
MBS9337198 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the dynein, axonemal, heavy chain 5 (DNAH5) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DNAH5. The ELISA analytical biochemical technique of the MBS9337198 kit is based on DNAH5 antibody-DNAH5 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DNAH5 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DNAH5. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Related Product Information for
DNAH5 elisa kit
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DNAH5 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9337198. Click to request current manual
NCBI/Uniprot data below describe general gene information for DNAH5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
529,021 Da
NCBI Official Full Name
dynein heavy chain 5, axonemal
NCBI Official Synonym Full Names
dynein, axonemal, heavy chain 5
NCBI Official Symbol
DNAH5  [Similar Products]
NCBI Official Synonym Symbols
HL1; PCD; CILD3; KTGNR; DNAHC5
  [Similar Products]
NCBI Protein Information
dynein heavy chain 5, axonemal; ciliary dynein heavy chain 5; axonemal beta dynein heavy chain 5; dynein, axonemal, heavy polypeptide 5
UniProt Protein Name
Dynein heavy chain 5, axonemal
UniProt Synonym Protein Names
Axonemal beta dynein heavy chain 5; Ciliary dynein heavy chain 5
Protein Family
UniProt Gene Name
DNAH5  [Similar Products]
UniProt Synonym Gene Names
DNAHC5; HL1; KIAA1603  [Similar Products]
UniProt Entry Name
DYH5_HUMAN
NCBI Summary for DNAH5
This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
UniProt Comments for DNAH5
DNAH5: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Defects in DNAH5 are the cause of primary ciliary dyskinesia type 3 (CILD3). CILD3 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAH5 are a cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Belongs to the dynein heavy chain family.

Protein type: Motor; Microtubule-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: microtubule; axonemal dynein complex; axoneme

Molecular Function: ATPase activity; microtubule motor activity; ATP binding

Biological Process: metabolic process; lateral ventricle development

Disease: Ciliary Dyskinesia, Primary, 3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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