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DNAJC3 cdna clone

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Catalog # MBS1266007
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
DNAJC3 cdna clone
Product Name

DNAJC3, cDNA Clone

Popular Item
Full Product Name

DNAJC3 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggtggccc ccggctccgt gaccagccgg ctgggctcgg tattcccctt cctgctagtc ctggtggatc tgcagtacga aggtgctgaa tgtggagtaa atgcagatgt tgagaaacat cttgaattgg gcaagaaatt acttgcagct ggacagctag ctgatgcttt atctcagttt catgctgccg tagatggtga ccctgataac tatattgctt attatcggag ggctactgtc tttttagcta tgggcaaatc aaaagctgca cttcctgatt taactaaagt gattcaattg aagatggact tcactgcagc aagattacag agaggtcact tattactcaa acaaggaaaa cttgatgaag cagaagatga ttttaaaaaa gtggtgtttc ctgttccttc tctgttggga ctccagcgtt ctctcctaga tgatctatac ttgctatttt ggttcttcct tatgaagaag gtgactttca gatgcctctc gtcagccatc tctgaatgcc ttcctcagtc tttaaatttg atgaagttca atttgttgat ttccttttta cttctgtgga ctgtgcgttt ggtgtcatgt ctaagaagta ttcactacgc cgtaggatct aaaacttttc tcatatcttc taaaagtttt atggttttgt gttttatttt taagcccata gtctatttga gttaa
OMIM
601184
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DNAJC3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DNAJC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,580 Da
NCBI Official Full Name
Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 3, mRNA
NCBI Official Synonym Full Names
DnaJ heat shock protein family (Hsp40) member C3
NCBI Official Symbol
DNAJC3  [Similar Products]
NCBI Official Synonym Symbols
P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK
  [Similar Products]
NCBI Protein Information
dnaJ homolog subfamily C member 3
UniProt Protein Name
DnaJ homolog subfamily C member 3
UniProt Synonym Protein Names
Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58
Protein Family
UniProt Gene Name
DNAJC3  [Similar Products]
UniProt Synonym Gene Names
P58IPK; PRKRI; ER-resident protein ERdj6; ERdj6; Protein kinase inhibitor p58  [Similar Products]
UniProt Entry Name
DNJC3_HUMAN
NCBI Summary for DNAJC3
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
UniProt Comments for DNAJC3
DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.

Protein type: Endoplasmic reticulum; Inhibitor; Chaperone; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 13q32.1

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; membrane

Molecular Function: protein kinase binding; protein kinase inhibitor activity

Biological Process: negative regulation of apoptosis

Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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