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Dnase1l3 recombinant protein :: Deoxyribonuclease gamma (Dnase1l3) Recombinant Protein

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Catalog # MBS1075400
Unit / Price
  0.05 mg (E-Coli)  /  $690 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $800 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $925 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,035 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,085 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,230 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,275 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,490 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,535 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,945 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,950 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,070 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,015 +3 FREE 8GB USB
Dnase1l3 recombinant protein
Product Name

Deoxyribonuclease gamma (Dnase1l3), Recombinant Protein

Popular Item
Full Product Name

Recombinant Rat Deoxyribonuclease gamma (Dnase1l3)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1075400 COA
Sequence Positions
26-310aa, Full Length of Mature Protein
Sequence
LRLCSFNVRS FGESKKENHN AMDIIVKIIK RCDLILLMEI KDSNNNICPM LMEKLNGNSR RSTTYNYVIS SRLGRNTYKE QYAFLYKEKL VSVKAKYLYH DYQDGDTDVF SREPFVVWFQ APFTAAKDFV IVPLHTTPET SVKEIDELAD VYTDVRRRWK AENFIFMGDF NAGCSYVPKK AWKNIRLRTD PNFVWLIGDQ EDTTVKKSTS CAYDRIVLRG QEIVNSVVPR SSGVFDFQKA YELSEEEALD VSDHFPVEFK LQSSRAFTNS RKSVSLKKKK KGSRS
3D Structure
ModBase 3D Structure for O89107
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Dnase1l3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Dnase1l3 recombinant protein
This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
NCBI/Uniprot data below describe general gene information for Dnase1l3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
35,708 Da
NCBI Official Full Name
deoxyribonuclease gamma
NCBI Official Synonym Full Names
deoxyribonuclease 1-like 3
NCBI Official Symbol
Dnase1l3  [Similar Products]
NCBI Protein Information
deoxyribonuclease gamma
UniProt Protein Name
Deoxyribonuclease gamma
UniProt Synonym Protein Names
DNaseY; Deoxyribonuclease I-like 3; DNase I-like 3
Protein Family
UniProt Gene Name
Dnase1l3  [Similar Products]
UniProt Synonym Gene Names
DNase gamma; DNase I-like 3  [Similar Products]
NCBI Summary for Dnase1l3
Ca2+/Mg2+ dependent endonuclease that catalyzes cleavage of both single and double stranded DNA; may play a role in apoptotic DNA fragmentation [RGD, Feb 2006]
UniProt Comments for Dnase1l3
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (PubMed:7957253). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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