NP_001005361.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,064 Da
NCBI Official Full Name
dynamin-2 isoform 2
NCBI Official Synonym Full Names
dynamin 2
NCBI Official Synonym Symbols
DYN2; CMT2M; DYNII; CMTDI1; CMTDIB; DI-CMTB [Similar Products]
NCBI Protein Information
dynamin-2; dynamin II
UniProt Protein Name
Dynamin-2
UniProt Synonym Gene Names
UniProt Entry Name
DYN2_HUMAN
NCBI Summary for DNM2
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
UniProt Comments for DNM2
DYN2: a cytoplasmic microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. May mediate the conventional clathrin-mediated uptake of surface receptors. Expressed in the postsynaptic density of neuronal cells. Two alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Vesicle; Microtubule-binding; EC 3.6.5.5; Hydrolase
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: Golgi membrane; Golgi apparatus; microtubule; postsynaptic membrane; growth cone; focal adhesion; postsynaptic density; cytoplasm; plasma membrane; coated pit; midbody; cytosol
Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; microtubule binding; SH3 domain binding
Biological Process: receptor-mediated endocytosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; synaptic vesicle transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; transferrin transport; endocytosis; regulation of axon extension; signal transduction; nitric oxide metabolic process; regulation of transcription, DNA-dependent; receptor internalization; regulation of nitric-oxide synthase activity; post-Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; neurite morphogenesis
Disease: Lethal Congenital Contracture Syndrome 5; Myopathy, Centronuclear, 1; Charcot-marie-tooth Disease, Dominant Intermediate B
Research Articles on DNM2
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Products associated with DNM2 elisa kit
Pathways associated with DNM2 elisa kit
Diseases associated with DNM2 elisa kit
Disease Name |
Pubmed Publications |
Nervous System Diseases Antibodies |
>45 publications with DNM2 and Nervous System Diseases |
Myopathies, Structural, Congenital Antibodies |
>27 publications with DNM2 and Myopathies, Structural, Congenital |
MYOPATHY, CENTRONUCLEAR, 1 Antibodies |
>13 publications with DNM2 and MYOPATHY, CENTRONUCLEAR, 1 |
Atrophy Antibodies |
>7 publications with DNM2 and Atrophy |
Charcot-Marie-Tooth Disease, Dominant Intermediate B Antibodies |
>4 publications with DNM2 and Charcot-Marie-Tooth Disease, Dominant Intermediate B |
Immune System Diseases Antibodies |
>3 publications with DNM2 and Immune System Diseases |
Cardiovascular Diseases Antibodies |
>2 publications with DNM2 and Cardiovascular Diseases |
Neoplasms Antibodies |
>2 publications with DNM2 and Neoplasms |
Cognition Disorders Antibodies |
>1 publications with DNM2 and Cognition Disorders |
Edema Antibodies |
>1 publications with DNM2 and Edema |
Organs/Tissues associated with DNM2 elisa kit
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