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DOC1 recombinant protein :: Anaphase-promoting complex subunit DOC1 (DOC1) Recombinant Protein

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Catalog # MBS1124793
Unit / Price
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  0.05 mg (E-Coli)  /  $650 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $770 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $875 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $965 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,000 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,045 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,245 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,450 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,450 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,875 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,890 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,025 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,940 +3 FREE 8GB USB
DOC1 recombinant protein
Product Name

Anaphase-promoting complex subunit DOC1 (DOC1), Recombinant Protein

Full Product Name

Recombinant Saccharomyces cerevisiae Anaphase-promoting complex subunit DOC1 (DOC1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-250aa, full length protein
Sequence
MDPIGINKVL DHLAPSELIK PVKSCHNKPS VLVLDDRIVD AATKDLYVNG FQEEIQYQNP TPENLQHMFH QGIEILDSAR MINVTHLALW KPSSFKLGNP VDFALDDNYD TFWQSDGGQP HQLDIMFSKR MDICVMAIFF SMIADESYAP SLVKVYAGHS PSDARFYKML EVRNVNGWVA LRFLDNREDD QLLKCQFIRL LFPVNHENGK DTHLRGIRLY VPSNEPHQDT HEWAQTLPET NNVFQDAILR
3D Structure
ModBase 3D Structure for P53068
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DOC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DOC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,777 Da
NCBI Official Full Name
anaphase promoting complex subunit DOC1
NCBI Official Symbol
NCBI Official Synonym Symbols
APC10
  [Similar Products]
NCBI Protein Information
anaphase promoting complex subunit DOC1
UniProt Protein Name
Anaphase-promoting complex subunit DOC1
UniProt Synonym Protein Names
Destruction of cyclin B protein 1
UniProt Gene Name
UniProt Synonym Gene Names
APC10  [Similar Products]
UniProt Comments for DOC1
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. DOC1 is required, together with the coactivators CDH1 and CDC20, for recognition and binding of the substrates.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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