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DSTN recombinant protein

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Catalog # MBS204618
Unit / Price
  0.1 mg  /  $310 +1 FREE 8GB USB
  0.5 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

DSTN, Recombinant Protein

Popular Item
Full Product Name

DSTN, 1-165aa, Human, His tag, E Coli

Product Synonym Names
Destrin (actin depolymerizing factor); ACTDP; ADF; bA462D18.2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE KLGGSLIVAF EGCPVLEHHH HHH
OMIM
S65738 mRNA
3D Structure
ModBase 3D Structure for P60981
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of DSTN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DSTN recombinant protein
Destrin (actin depolymerizing factor), also known as DSTN, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. DSTN is a small phosphoinositide-sensitive actin-binding protein capable of depolymerizing actin-filaments in vitro. It is found in various epithelial and endothelial cells but is practically absent from adult mouse heart and skeletal muscle cells. DSTN shares 71% sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. Recombinant human DSTN protein, fused to His-tag at C-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for DSTN recombinant protein
Applications Tested/Suitable for DSTN recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for DSTN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19.5 kDa (173aa) confirmed by MALDI-TOF
NCBI Official Full Name
destrin isoform a
NCBI Official Synonym Full Names
destrin, actin depolymerizing factor
NCBI Official Symbol
NCBI Official Synonym Symbols
ADF; ACTDP; HEL32; bA462D18.2
  [Similar Products]
NCBI Protein Information
destrin
UniProt Protein Name
Destrin
UniProt Synonym Protein Names
Actin-depolymerizing factor; ADF
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ACTDP; DSN; ADF  [Similar Products]
NCBI Summary for DSTN
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DSTN
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
Product References and Citations for DSTN recombinant protein
Nishida E., et al. (1985) Biochemistry. 24:6624-6630.; Kanamori T., et al. (1995) J Biol Chem. 270: 8061-8067.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withDSTN recombinant protein
 Reference Product  PubMed Publications
 WDR1 recombinant protein  >2 publications with DSTN and WDR1
Pathways associated with DSTN recombinant protein
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