NP_004412.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,881 Da
NCBI Official Full Name
segment polarity protein dishevelled homolog DVL-1
NCBI Official Synonym Full Names
dishevelled segment polarity protein 1
NCBI Protein Information
segment polarity protein dishevelled homolog DVL-1
UniProt Protein Name
Segment polarity protein dishevelled homolog DVL-1
UniProt Synonym Protein Names
DSH homolog 1
UniProt Synonym Gene Names
UniProt Entry Name
DVL1_HUMAN
NCBI Summary for DVL1
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
UniProt Comments for DVL1
DVL1: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs to the DSH family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: microtubule; growth cone; cell soma; clathrin-coated vesicle; axon; cytoplasmic membrane-bound vesicle; cytoplasm; dendrite; synapse; cytoplasmic vesicle; cytosol; lateral plasma membrane
Molecular Function: identical protein binding; protein binding; enzyme binding; frizzled binding; Rac GTPase binding; protein kinase binding
Biological Process: neural tube development; transcription from RNA polymerase II promoter; axon guidance; Wnt receptor signaling pathway; prepulse inhibition; convergent extension involved in neural plate elongation; axon extension; Wnt receptor signaling pathway, planar cell polarity pathway; dendrite morphogenesis; heart development; neurotransmitter secretion; positive regulation of transcription, DNA-dependent; regulation of neurotransmitter levels; social behavior; Wnt receptor signaling pathway through beta-catenin; receptor clustering; cytoplasmic microtubule organization and biogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; collateral sprouting; synapse organization and biogenesis; negative regulation of protein kinase activity; negative regulation of protein binding; positive regulation of Wnt receptor signaling pathway; neuromuscular junction development
Disease: Robinow Syndrome, Autosomal Dominant; Robinow Syndrome, Autosomal Dominant 2
Research Articles on DVL1
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Products associated with DVL1 sirna
Pathways associated with DVL1 sirna
Diseases associated with DVL1 sirna
Organs/Tissues associated with DVL1 sirna
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