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DYNC1H1 elisa kit :: Goat Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA Kit

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Catalog # MBS7204951
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DYNC1H1 elisa kit
Product Name

Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1), ELISA Kit

Full Product Name

Goat Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
614563
Species Reactivity
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of DYNC1H1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for DYNC1H1purchase
MBS7204951 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DYNC1H1. The ELISA analytical biochemical technique of the MBS7204951 kit is based on DYNC1H1 antibody-DYNC1H1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DYNC1H1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DYNC1H1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for DYNC1H1 elisa kit
NCBI/Uniprot data below describe general gene information for DYNC1H1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
532,408 Da
NCBI Official Full Name
cytoplasmic dynein 1 heavy chain 1
NCBI Official Synonym Full Names
dynein, cytoplasmic 1, heavy chain 1
NCBI Official Symbol
DYNC1H1  [Similar Products]
NCBI Official Synonym Symbols
p22; DHC1; DNCL; DYHC; HL-3; DHC1a; DNCH1; DNECL; Dnchc1; SMALED1
  [Similar Products]
NCBI Protein Information
cytoplasmic dynein 1 heavy chain 1; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy polypeptide 1
UniProt Protein Name
Cytoplasmic dynein 1 heavy chain 1
UniProt Synonym Protein Names
Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic
Protein Family
UniProt Gene Name
DYNC1H1  [Similar Products]
UniProt Synonym Gene Names
DHC1; DNCH1; DNCL; DNECL; DYHC; KIAA0325  [Similar Products]
UniProt Entry Name
DYHC1_HUMAN
NCBI Summary for DYNC1H1
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
UniProt Comments for DYNC1H1
DNCH1: Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Defects in DYNC1H1 are the cause of Charcot-Marie-Tooth disease type 2O (CMT2O). CMT2O is anaxonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Defects in DYNC1H1 are the cause of mental retardation autosomal dominant type 13 (MRD13). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD13 is associated with variable neuronal migration defects and mild dysmorphic features. Some patients may also show signs of peripheral neuropathy, such as abnormal gait and hyporeflexia. Defects in DYNC1H1 are the cause of spinal muscular atrophy, lower extremity, autosomal dominant (SMALED). A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMALED is characterized by muscle weakness predominantly affecting the proximal lower extremities. Belongs to the dynein heavy chain family.

Protein type: Motility/polarity/chemotaxis; Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: centrosome; microtubule; membrane; cytoplasmic dynein complex; cytosol; filopodium

Molecular Function: protein binding; ATPase activity; dynein light intermediate chain binding; microtubule motor activity; ATP binding

Biological Process: stress granule assembly; mitotic spindle organization and biogenesis; transport; metabolic process; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytoplasmic mRNA processing body assembly; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based movement

Disease: Charcot-marie-tooth Disease, Axonal, Type 2o; Spinal Muscular Atrophy, Lower Extremity-predominant, 1, Autosomal Dominant; Mental Retardation, Autosomal Dominant 13
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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