P06790.2
[Other Products]
UniProt Primary Accession #
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[Other Products]
Molecular Weight
43.3 kDa
NCBI Official Full Name
Regulatory protein E2
UniProt Protein Name
Regulatory protein E2
UniProt Entry Name
VE2_HPV18
UniProt Comments for E2
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Product References and Citations for E2 recombinant protein
Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987)
TaqI is a single cut enzyme for HPV-18.Meissner J.Nucleic Acids Res. 21:1041-1041(1993)
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