AAF62100.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ECSIT
NCBI Official Synonym Full Names
ECSIT signalling integrator
NCBI Official Synonym Symbols
NCBI Protein Information
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; ECSIT homolog; likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved
UniProt Protein Name
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
UniProt Synonym Protein Names
Protein SITPEC
UniProt Entry Name
ECSIT_HUMAN
UniProt Comments for ECSIT
Function: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development
By similarity.Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Subunit structure: Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment
By similarity. Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, CIA30, ECSIT, and ACAD9
By similarity. Interacts with NDUFAF1. Ref.5
Subcellular location: Cytoplasm. Nucleus. Mitochondrion Ref.5.
Sequence similarities: Belongs to the ECSIT family.
Research Articles on ECSIT
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Products associated with ECSIT peptide
Pathways associated with ECSIT peptide
Diseases associated with ECSIT peptide
Organs/Tissues associated with ECSIT peptide
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