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eIF5A recombinant protein

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Catalog # MBS203210
Unit / Price
  0.1 mg  /  $310 +1 FREE 8GB USB
  0.5 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

eIF5A, Recombinant Protein

Popular Item
Full Product Name

eIF5A, 1-154aa, Human, E Coli

Product Synonym Names
Eukaryotic translation initiation factor 5A isoform B; EIF-5A; EIF5A1; eIF5AI; Eukaryotic translation initiation factor 5A isoform B eIF 4D; EIF 5A; eIF 5A 1; eIF 5A1; eIF4D; uORF; uORF A; Eukaryotic initiation factor 5A; Rev binding factor; Eukaryotic initiation factor 5A isoform 1; MGC99547; Eukaryotic translation initiation factor 5A; Eukaryotic translation initiation factor 5A 1; MGC104255.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK
OMIM
M23419 mRNA
3D Structure
ModBase 3D Structure for P63241
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 50 mM Tris-HCl Buffer pH 7.5 containing 10 % glycerol
Concentration
1.0 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of eIF5A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
eIF5A recombinant protein
Eukaryotic translation initiation factor 5A (eIF5A) is the only protein Known to contain unusual amino acid formed by the action of deoxyhypusine synthase and deoxyhypusine hydroxylase using spermidine as the substrate. This protein was previously reported to be involved in the first step of peptide bond formation in translation; however more recent work implicates it as a universally conserved translation elongation factor. Modulation of eIF5A has been linked to proliferation and cancer. Recombinant human eIF5A protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Categories/Family for eIF5A recombinant protein
Applications Tested/Suitable for eIF5A recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for eIF5A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
16.8 kDa (154 aa), confirmed by MALDI-TOF.
NCBI Official Full Name
eukaryotic translation initiation factor 5A-1 isoform B
UniProt Protein Name
Eukaryotic translation initiation factor 5A-1
UniProt Synonym Protein Names
Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D
UniProt Gene Name
EIF5A  [Similar Products]
UniProt Synonym Gene Names
eIF-5A-1; eIF-5A1; eIF-5A  [Similar Products]
UniProt Comments for eIF5A
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Product References and Citations for eIF5A recombinant protein
Saini P, et al. (2009). Nature. 459 (7243):118-21; Gosslau A., et al. (2009). J Cell Physiol. 219 (2):485-93;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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