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ENSA recombinant protein :: Alpha-endosulfine (ENSA) Recombinant Protein

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Catalog # MBS950908
Unit / Price
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  0.05 mg (E-Coli)  /  $515 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $660 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $685 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $755 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $900 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $900 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,015 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,130 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,135 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,290 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,605 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,690 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,855 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,640 +3 FREE 8GB USB
ENSA recombinant protein
Product Name

Alpha-endosulfine (ENSA), Recombinant Protein

Full Product Name

Recombinant Bovine Alpha-endosulfine (ENSA)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-121aa, Full Length of Mature Protein
Sequence
SQKQEEENPA EETGEEKQDT QEKEGILPEK AEEAKLKAKY PSLGQKPGGS DFLMKRLQKG QKYFDSGDYN MAKAKMKNKQ LPSAGPDKNL VTGDHIPTPQ DLPQRKSSLV TSKLAGGQVE
3D Structure
ModBase 3D Structure for P68210
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Bovine
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ENSA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ENSA recombinant protein
This protein belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8
SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
NCBI/Uniprot data below describe general gene information for ENSA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,948 Da
NCBI Official Full Name
alpha-endosulfine isoform 2
NCBI Official Synonym Full Names
endosulfine alpha
NCBI Official Symbol
NCBI Protein Information
alpha-endosulfine
UniProt Protein Name
Alpha-endosulfine
UniProt Synonym Protein Names
ARPP-19e
Protein Family
UniProt Gene Name
UniProt Comments for ENSA
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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