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EP300 elisa kit :: Plant E1A Binding Protein P300 (EP300) ELISA Kit

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Catalog # MBS9373733
Unit / Price Please Inquire
EP300 elisa kit
Product Name

E1A Binding Protein P300 (EP300), ELISA Kit

Also Known As

Plant E1A Binding Protein P300 (EP300) ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Sequence Length
2414
OMIM
602700
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of EP300 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forEP300purchase
MBS9373733 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the E1A Binding Protein P300 (EP300) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EP300. The ELISA analytical biochemical technique of the MBS9373733 kit is based on EP300 antibody-EP300 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EP300 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EP300. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for EP300. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
264,161 Da
NCBI Official Full Name
E1A binding protein p300
NCBI Official Synonym Full Names
E1A binding protein p300
NCBI Official Symbol
EP300  [Similar Products]
NCBI Official Synonym Symbols
p300; KAT3B; RSTS2
  [Similar Products]
NCBI Protein Information
histone acetyltransferase p300
UniProt Protein Name
Histone acetyltransferase p300
UniProt Synonym Protein Names
E1A-associated protein p300
Protein Family
UniProt Gene Name
EP300  [Similar Products]
UniProt Synonym Gene Names
P300; p300 HAT  [Similar Products]
UniProt Entry Name
EP300_HUMAN
NCBI Summary for EP300
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
UniProt Comments for EP300
p300: a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2.

Protein type: Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: acetyltransferase activity; androgen receptor binding; beta-catenin binding; chromatin binding; damaged DNA binding; DNA binding; histone acetyltransferase activity; lysine N-acetyltransferase activity; nuclear hormone receptor binding; peptide N-acetyltransferase activity; protein binding; protein C-terminus binding; transcription activator binding; transcription coactivator activity; transcription factor binding; transferase activity, transferring acyl groups

Biological Process: apoptosis; circadian rhythm; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; fat cell differentiation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; N-terminal peptidyl-lysine acetylation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; Notch signaling pathway; positive regulation of gene expression, epigenetic; positive regulation of interferon type I production; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; protein amino acid acetylation; protein stabilization; regulation of autophagy; regulation of cell cycle; regulation of transcription, DNA-dependent; response to estrogen stimulus; response to hypoxia; stimulatory C-type lectin receptor signaling pathway; transcription-coupled nucleotide-excision repair

Disease: Colorectal Cancer; Rubinstein-taybi Syndrome 1; Rubinstein-taybi Syndrome 2
Research Articles on EP300
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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