NP_109636.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28.3 kDa
NCBI Official Full Name
endoplasmic reticulum aminopeptidase 1
NCBI Official Synonym Full Names
endoplasmic reticulum aminopeptidase 1
NCBI Protein Information
endoplasmic reticulum aminopeptidase 1; A-LAP; ARTS-1; PILS-AP; aminopeptidase PILS; VEGF-induced aminopeptidase; adipocyte-derived leucine aminopeptidase; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
UniProt Protein Name
Endoplasmic reticulum aminopeptidase 1
UniProt Synonym Protein Names
ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; VEGF-induced aminopeptidase
UniProt Synonym Gene Names
UniProt Entry Name
ERAP1_MOUSE
UniProt Comments for Erap1
ARTS1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.11.-; Membrane protein, integral; Protease
Cellular Component: extracellular space; intracellular membrane-bound organelle; membrane; endoplasmic reticulum lumen; endoplasmic reticulum; cytoplasm; integral to membrane; extracellular region
Molecular Function: peptidase activity; interleukin-6 receptor binding; metalloexopeptidase activity; metallopeptidase activity; hydrolase activity; zinc ion binding; metal ion binding; aminopeptidase activity; tumor necrosis factor receptor binding
Biological Process: positive regulation of angiogenesis; immune system process; membrane protein ectodomain proteolysis; proteolysis
Research Articles on Erap1
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Pathways associated with Erap1 recombinant protein
Diseases associated with Erap1 recombinant protein
Organs/Tissues associated with Erap1 recombinant protein
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