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Erap1 recombinant protein :: Endoplasmic reticulum aminopeptidase 1 (Erap1), partial Recombinant Protein

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Catalog # MBS1361542
Unit / Price
  0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $170 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $255 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $400 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $640 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,000 +1 FREE 8GB USB
SDS-PAGE
Product Name

Endoplasmic reticulum aminopeptidase 1 (Erap1), partial, Recombinant Protein

Popular Item
Also Known As

Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 (Erap1), partial

Product Synonym Names
Endoplasmic reticulum aminopeptidase 1; EC=3.4.11.-; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; VEGF-induced aminopeptidase
Product Synonym Gene Name
Erap1; Appils; Arts1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1361542 COA
Sequence Positions
731-930aa; Partial
Sequence Length
930
Sequence
PCVQRAERYF REWKSSNGNM SIPIDVTLAV FAVGAQNTEG WDFLYSKYQS SLSSTEKSQI EFSLCTSKDP EKLQWLLDQS FKGEIIKTQE FPHILTLIGR NPVGYPLAWK FLRENWNKLV QKFELGSSSI AHMVMGTTDQ FSTRARLEEV KGFFSSLKEN GSQLRCVQQT IETIEENIRW MDKNFDKIRL WLQKEKPELL
3D Structure
ModBase 3D Structure for Q9EQH2
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Erap1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Erap1 recombinant protein
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity).
Product Categories/Family for Erap1 recombinant protein

Erap1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Erap1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,599 Da
NCBI Official Full Name
endoplasmic reticulum aminopeptidase 1
NCBI Official Synonym Full Names
endoplasmic reticulum aminopeptidase 1
NCBI Official Symbol
Erap1  [Similar Products]
NCBI Official Synonym Symbols
Arts1; ERAAP; PILSA; PILSAP
  [Similar Products]
NCBI Protein Information
endoplasmic reticulum aminopeptidase 1; A-LAP; ARTS-1; PILS-AP; aminopeptidase PILS; VEGF-induced aminopeptidase; adipocyte-derived leucine aminopeptidase; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
UniProt Protein Name
Endoplasmic reticulum aminopeptidase 1
UniProt Synonym Protein Names
ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; VEGF-induced aminopeptidase
UniProt Gene Name
Erap1  [Similar Products]
UniProt Synonym Gene Names
Appils; Arts1; A-LAP; PILS-AP  [Similar Products]
UniProt Entry Name
ERAP1_MOUSE
UniProt Comments for Erap1
ARTS1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.11.-; Membrane protein, integral; Protease

Cellular Component: extracellular space; intracellular membrane-bound organelle; membrane; endoplasmic reticulum lumen; endoplasmic reticulum; cytoplasm; integral to membrane; extracellular region

Molecular Function: peptidase activity; interleukin-6 receptor binding; metalloexopeptidase activity; metallopeptidase activity; hydrolase activity; zinc ion binding; metal ion binding; aminopeptidase activity; tumor necrosis factor receptor binding

Biological Process: positive regulation of angiogenesis; immune system process; membrane protein ectodomain proteolysis; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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