NP_034284.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
146,855 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-4
NCBI Official Synonym Full Names
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
NCBI Protein Information
receptor tyrosine-protein kinase erbB-4; avian erythroblastosis oncogene B 4; proto-oncogene-like protein c-ErbB-4
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-4
UniProt Synonym Protein Names
Proto-oncogene-like protein c-ErbB-4Cleaved into the following chain:ERBB4 intracellular domain; 4ICD; E4ICDAlternative name(s):s80HER4
UniProt Synonym Gene Names
UniProt Entry Name
ERBB4_MOUSE
UniProt Comments for ERBB4
HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; EGFR family
Cellular Component: mitochondrion; membrane; basolateral plasma membrane; postsynaptic density; cytoplasm; plasma membrane; integral to membrane; caveola; nucleus; receptor complex; lipid raft
Molecular Function: transferase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding; protein kinase activity; epidermal growth factor receptor binding
Biological Process: lactation; synapse maturation; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; heart development; positive regulation of transcription, DNA-dependent; multicellular organismal development; signal transduction; embryonic pattern specification; regulation of cell migration; olfactory bulb interneuron differentiation; protein amino acid phosphorylation; positive regulation of glucose import; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; nervous system development; cell migration; cell fate commitment; transcription, DNA-dependent; positive regulation of synaptic transmission, GABAergic; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; mitochondrial fragmentation during apoptosis; surfactant homeostasis; phosphorylation; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on ERBB4
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Pathways associated with ERBB4 elisa kit
Diseases associated with ERBB4 elisa kit
Organs/Tissues associated with ERBB4 elisa kit
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