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EREG recombinant protein :: Epiregulin Recombinant Protein

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Catalog # MBS539384
Unit / Price
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  0.025 mg  /  $310 +1 FREE 8GB USB
EREG recombinant protein
Product Name

Epiregulin (EREG), Recombinant Protein

Full Product Name

Epiregulin protein

Product Synonym Names
EREG protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Region of Epiregulin protein correspond ing to amino acids MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL .
OMIM
602061
3D Structure
ModBase 3D Structure for O14944
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a lyophilized powder.
Protein Type
Recombinant
Biological Significance
Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells is approximately 2.0 ng/ml, corresponding to a specific activity of approximately 5 x 10^5units/mg.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of EREG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
EREG recombinant protein
Purified recombinant Human Epiregulin protein
Applications Tested/Suitable for EREG recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for EREG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
EREG, partial
NCBI Official Synonym Full Names
epiregulin
NCBI Official Symbol
NCBI Official Synonym Symbols
ER; Ep; EPR
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NCBI Protein Information
proepiregulin
UniProt Protein Name
Proepiregulin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
EREG_HUMAN
NCBI Summary for EREG
This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]
UniProt Comments for EREG
Epiregulin: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to plasma membrane; extracellular region

Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: response to peptide hormone stimulus; nerve growth factor receptor signaling pathway; wound healing; activation of MAPK activity; positive regulation of interleukin-6 biosynthetic process; positive regulation of smooth muscle cell proliferation; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; primary follicle stage, oogenesis; cell-cell signaling; positive regulation of epidermal growth factor receptor activity; positive regulation of innate immune response; positive regulation of cell proliferation; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; positive regulation of cytokine production; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; luteinizing hormone signaling pathway; keratinocyte proliferation; oocyte maturation; ovulation; keratinocyte differentiation; organ morphogenesis; positive regulation of protein kinase activity; mRNA transcription; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation; positive regulation of DNA replication
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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