NP_036821.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
67,030 Da
NCBI Official Full Name
estrogen receptor
NCBI Official Synonym Full Names
estrogen receptor 1
NCBI Protein Information
estrogen receptor; Er alpha; estradiol receptor; estrogen receptor protein; estrogen receptor 1 (alpha); estrogen receptor alpha variant delta 4; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha c-terminus splice variant 1-2
UniProt Protein Name
Estrogen receptor
UniProt Synonym Protein Names
ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
UniProt Synonym Gene Names
UniProt Entry Name
ESR1_RAT
NCBI Summary for ESR1
acts as a transcriptional activator when bound to estrogen; may play a role in myocardial regulation [RGD, Feb 2006]
UniProt Comments for ESR1
Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades
Research Articles on ESR1
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Products associated with ESR1 elisa kit
Pathways associated with ESR1 elisa kit
Diseases associated with ESR1 elisa kit
Organs/Tissues associated with ESR1 elisa kit
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