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F12 recombinant protein :: Coagulation Factor XIIa Recombinant Protein

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Catalog # MBS135876
Unit / Price
  0.05 mg  /  $470 +1 FREE 8GB USB
  0.1 mg  /  $660 +1 FREE 8GB USB
Testing Data
Product Name

Coagulation Factor XIIa (F12), Recombinant Protein

Popular Item
Full Product Name

Recombinant Mouse Coagulation Factor XIIa

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 13; NC_000079.6 (55417966..55426802, complement). Location: 13; 13 B2
3D Structure
ModBase 3D Structure for Q80YC5
Host
Insect cell culture
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen liquid
Concentration
0.4 mg/ml (lot specific)
Aliquot
1 x 0.1 mg
Volume
0.25 ml
Buffer
4 mM Sodium Acetate; 0.15 M NaCl; pH 5.3
Extinction Coefficient
1.73
Preparation and Storage
Store at -70°C.
Shelf Life: 3 years from delivery
Ships with Dry Ice.
Other Notes
Small volumes of F12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
F12 recombinant protein
Mouse Factor alpha-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system of blood coagulation. Recombinant insect cell derived mouse Factor alpha-XIIa is manufactured by autoactivation of recombinant mouse Factor XII with Dextran Sulfate and re-purifed to remove the activator. >95 percent activation is observed on SDS-PAGE. The protein purity is determined by SDS-PAGE and activity is determined via complementation in a APTT clotting assay using Factor XII immuno-deficient human plasma. Custom mutants of Factor XII are also available, please contact us for details.

Testing Data of F12 recombinant protein
F12 recombinant protein Testing Data image
NCBI/Uniprot data below describe general gene information for F12. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,000 (Approximate)
NCBI Official Full Name
coagulation factor XII
NCBI Official Synonym Full Names
coagulation factor XII (Hageman factor)
NCBI Official Symbol
NCBI Official Synonym Symbols
HAF; FXII
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NCBI Protein Information
coagulation factor XII; hageman factor
UniProt Protein Name
Coagulation factor XII
UniProt Synonym Protein Names
Hageman factor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
FA12_MOUSE
NCBI Summary for F12
This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]
UniProt Comments for F12
F12: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Defects in F12 are the cause of factor XII deficiency (FA12D); also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). Defects in F12 are the cause of hereditary angioedema type 3 (HAE3); also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal. Belongs to the peptidase S1 family.

Protein type: Protease; Secreted; Chaperone; EC 3.4.21.38; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity

Biological Process: response to misfolded protein; positive regulation of blood coagulation; proteolysis; protein autoprocessing; fibrinolysis; hemostasis; plasma kallikrein-kinin cascade; regulation of blood coagulation; positive regulation of fibrinolysis; zymogen activation; protein processing; blood coagulation; Factor XII activation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with F12 recombinant protein
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