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F8 plasma :: Factor VIII Plasma

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Catalog # MBS514010
Unit / Price
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  1 mL  /  $120 +1 FREE 8GB USB
F8 plasma
Product Name

Factor VIII (F8), Plasma

Popular Item
Full Product Name

Factor VIII Deficient Plasma

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS514010 MSDS
M14113 mRNA
Frozen Factor VIII deficient plasma.
Thaw 1 ml vials in 37°C waterbath for 5 minutes; for bulk volumes, thawing time will be dependent on bottle size.
Lot specific assay results;

PT (Stago Neoplastine C1 +): 12.6 sec
APTT (HemoslL APTT-SP): 80.1 sec
Fibrinogen (clottable): 3.22 g/L
FII (activity): 1.09 U/ml
FV (activity): 1.00 U/ml
FVII (activity): 0.90 U/ml
FVIII (activity): <0.01 U/ml
FIX (activity): 1.06 U/ml
FX (activity): 1.08 U/ml
FXI (activity): 0.70 U/ml
FXII (activity): 1.14 U/ml
FVIII Inhibitor assay (1:1, 120 min @ 37 degree C): Negative
Although this material was prepared with plasma collected from donors screened for CJD and which was tested at source and found negative for HBsAg, syphilis and antibodies to HIV and HeV an.d non-reactilleJof HIV-1 r.NA and HCV rNA by FDA approved tests, it should be har:1dled by personnel trained in the proper procedures for handling potential viral contaminants.
Preparation and Storage
Plasma is shipped frozen and should be stored below -60°C. Product is stable until date stated on vial label when stored at -60°C. Once thawed, plasma is stable for 4 hours at 2-8°C in original vial.
Shipping: Dry Ice
Other Notes
Small volumes of F8 plasma vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
F8 plasma
Pooled normal citrated human plasma depleted of Factor VIII using antibodies directed to Factor VIII immobilized on agarose beads. Plasma contains 20mM HEPES.
Product Categories/Family for F8 plasma
NCBI/Uniprot data below describe general gene information for F8. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
factor VIII
NCBI Official Synonym Full Names
coagulation factor VIII
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
coagulation factor VIII
UniProt Protein Name
Coagulation factor VIII
UniProt Synonym Protein Names
Antihemophilic factor; AHF
UniProt Gene Name
UniProt Synonym Gene Names
F8C; AHF  [Similar Products]
NCBI Summary for F8
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
UniProt Comments for F8
F8: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Defects in F8 are the cause of hemophilia A (HEMA). A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery. Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non- functional; i.e. the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein. Belongs to the multicopper oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular region; plasma membrane

Molecular Function: protein binding

Biological Process: blood coagulation; blood coagulation, intrinsic pathway; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; platelet degranulation

Disease: Hemophilia A
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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