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FADD recombinant protein

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Catalog # MBS203590
Unit / Price
  0.05 mg  /  $375 +1 FREE 8GB USB
  0.25 mg  /  $925 +1 FREE 8GB USB
SDS-Page
Product Name

FADD, Recombinant Protein

Also Known As

FADD, 1-208aa, Human, His tag, E Coli

Product Synonym Names
Fas-associated via death domain; GIG3; MORT1; Fas-associated via death domain; Fas-associated death domain FADD protein; Fas associated via death domain; Fas (TNFRSF6) associated via death domain; Fas associating death domain containing protein; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; Fas associating protein; GIG 3; MGC8528; Growth inhibiting gene 3 protein; MORT 1; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
208
Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMDPF LVLLHSVSSS LSSSELTELK FLCLGRVGKR KLERVQSGLD LFSMLLEQND LEPGHTELLR ELLASLRRHD LLRRVDDFEA GAAAGAAPGE EDLCAAFNVI CDNVGKDWRR LARQLKVSDT KIDSIEDRYP RNLTERVRES LRIWKNTEKE NATVAHLVGA LRSCQMNLVA DLVQEVQQAR DLQNRSGAMS PMSWNSDAST SEAS
OMIM
U24231 mRNA
3D Structure
ModBase 3D Structure for Q13158
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol.
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of FADD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FADD recombinant protein
FADD (Fas-associated protein with death domain) is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. This protein is implicated in survival/proliferation and cell cycle progression. FADD functions are also regulated via cellular sublocalization, protein phosphorylation, and inhibitory molecules. Recombinant FADD protein was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for FADD recombinant protein
Applications Tested/Suitable for FADD recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for FADD. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27.4 kDa (244aa), confirmed by MALDI-TOF.
NCBI Official Full Name
FAS-associated death domain protein
NCBI Official Synonym Full Names
Fas associated via death domain
NCBI Official Symbol
NCBI Official Synonym Symbols
GIG3; MORT1
  [Similar Products]
NCBI Protein Information
FAS-associated death domain protein
UniProt Protein Name
FAS-associated death domain protein
UniProt Synonym Protein Names
FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; Protein FADD
UniProt Gene Name
UniProt Synonym Gene Names
MORT1  [Similar Products]
NCBI Summary for FADD
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
UniProt Comments for FADD
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Product References and Citations for FADD recombinant protein
Eberstadt M., et al. (1998) Nature. 392 (6679):941-5. ; Matsuyoshi S., et al. (2006) Br J Cancer. 94 (4):532-9.;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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