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FASLG recombinant protein :: (Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG) Recombinant Protein

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Catalog # MBS958780
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $580 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $730 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $770 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $850 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $880 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $990 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,110 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,110 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,120 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,195 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,605 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,685 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,705 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,150 +2 FREE 8GB USB
FASLG recombinant protein
Product Name

(Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG), Recombinant Protein

Popular Item
Full Product Name

Recombinant Macaca mulatta (Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG)

Product Synonym Names
Recombinant (Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG); Tumor necrosis factor ligand superfamily member 6; CD95 ligand; CD95-L Fas antigen ligand; Fas ligand; FasL CD_antigen= CD178 Cleaved into the following 4 chains: 1. T
Product Synonym Gene Name
FASLG; CD95L, FASL, TNFSF6[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
102-280aa; Extracellular domain
Sequence
QLFHLQKELA ELRESTSQKH TASSLEKQIG HPSPPPEKKE QRKVAHLTGK PNSRSMPLEW EDTYGIVLLS GVKYKKGGLV INETGLYFVY SKVYFRGQSC TNLPLSHKVY MRNSKYPQDL VMMEGKMMSY CTTGQMWAHS SYLGAVFNLT SADHLYVNVS ELSLVNFEES QTFFGLYKL
Chromosome Location
Chromosome: 1; NC_007858.1 (202356172..202363032). Location: chromosome: 1
3D Structure
ModBase 3D Structure for P63307
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FASLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FASLG recombinant protein
This protein is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
NCBI/Uniprot data below describe general gene information for FASLG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,368 Da[Similar Products]
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 6
NCBI Official Symbol
FASLG  [Similar Products]
NCBI Official Synonym Symbols
FASL; CD95L; CD95-L; TNFSF6
  [Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 6; CD95 ligand; FAS antigen CD95; fas antigen ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 6
UniProt Synonym Protein Names
CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD_antigen: CD178Cleaved into the following 4 chains:Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble formAlternative name(s):Receptor-binding FasL ectodomain; Soluble Fas ligand; sFasL
UniProt Gene Name
FASLG  [Similar Products]
UniProt Synonym Gene Names
CD95L; FASL; TNFSF6; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA  [Similar Products]
UniProt Entry Name
TNFL6_MACMU
UniProt Comments for FASLG
Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects

By similarity.The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

By similarity.

Subunit structure: Homotrimer

Probable. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1

By similarity.

Subcellular location: Cell membrane; Single-pass type II membrane protein

By similarity. Cytoplasmic vesicle lumen

By similarity. Lysosome lumen

By similarity. Note: Colocalizes with the SPPL2A protease at the cell membrane. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination

By similarity.Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted

By similarity. Note: May be released into the extracellular fluid, probably by cleavage form the cell surface

By similarity.FasL intracellular domain: Nucleus

By similarity. Note: The FasL ICD cytoplasmic form is translocated into the nucleus

By similarity.

Post-translational modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells

By similarity.Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization

By similarity.N-glycosylated

By similarity.Monoubiquitinated

By similarity.

Sequence similarities: Belongs to the tumor necrosis factor family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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