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FBP1 recombinant protein :: Fructose-1,6-Bisphosphatase 1 Recombinant Protein

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Catalog # MBS143831
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,235 +2 FREE 8GB USB
FBP1 recombinant protein
Product Name

Fructose-1,6-Bisphosphatase 1 (FBP1), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Fructose-1,6-Bisphosphatase 1

Product Synonym Names
FBP1 Human; Fructose-1,6-Bisphosphatase 1 Human Recombinant; FBP1; FBP; D-fructose-1; 6-bisphosphate 1-phosphohydrolase 1; FBPase 1; Fructose-1; 6-bisphosphatase 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
338
Sequence
MGSSHHH HHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
OMIM
229700
3D Structure
ModBase 3D Structure for P09467
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
The FBP1 protein solution is formulated in 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of FBP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FBP1 recombinant protein
Description: The FBP1 Human recombinant protein is a single, non-glycosilated polypeptide chain produced in E Coli, having a molecular weight of 39kDa and containing 358 amino acids (1-338 a.a.). The FBP1 enzyme is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatography techniques.

Introduction: FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes part in the metabolism of pancreatic islet cells.
NCBI/Uniprot data below describe general gene information for FBP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,842 Da
NCBI Official Full Name
fructose-1,6-bisphosphatase 1
NCBI Official Synonym Full Names
fructose-1,6-bisphosphatase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
fructose-1,6-bisphosphatase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17; liver FBPase
UniProt Protein Name
Fructose-1,6-bisphosphatase 1
UniProt Synonym Protein Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
FBP; FBPase 1  [Similar Products]
UniProt Entry Name
F16P1_HUMAN
NCBI Summary for FBP1
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
UniProt Comments for FBP1
FBPase: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans, FBP1 in the liver and FBP2 in muscle. While both forms are inhibited allosterically by AMP, NAD and Ca2+, the muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Deficiency of FBP1 leads to a disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); EC 3.1.3.11; Mitochondrial; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - fructose and mannose

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: cytoplasm; cytosol

Molecular Function: monosaccharide binding; identical protein binding; protein binding; metal ion binding; fructose-bisphosphatase activity; AMP binding

Biological Process: dephosphorylation; carbohydrate metabolic process; glucose metabolic process; negative regulation of Ras protein signal transduction; regulation of gluconeogenesis; pathogenesis; negative regulation of cell growth; fructose 6-phosphate metabolic process; negative regulation of glycolysis; fructose metabolic process; protein homotetramerization; gluconeogenesis

Disease: Fructose-1,6-bisphosphatase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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