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FBXL2 (HGNC:13598) blocking peptide :: FBXL2 Blocking Peptide

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Catalog # MBS9225481
Unit / Price
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  0.1 mg  /  $155 +1 FREE 8GB USB
FBXL2 (HGNC:13598) blocking peptide
Product Name

FBXL2 (FBXL2 (HGNC:13598)), Blocking Peptide

Full Product Name

FBXL2 Antibody (C-term) Blocking Peptide

Product Synonym Names
F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2 ; F-box protein FBL2/FBL3; FBXL2
Antibody/Peptide Pairs
FBXL2 peptide (MBS9225481) is used for blocking the activity of FBXL2 antibody (MBS9212225)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605652
3D Structure
ModBase 3D Structure for Q9UKC9
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Membrane; Lipid-anchor
Tissue Location
Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of FBXL2 (HGNC:13598) blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FBXL2 (HGNC:13598) blocking peptide
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G(0). SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
NCBI/Uniprot data below describe general gene information for FBXL2 (HGNC:13598). It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,613 Da
NCBI Official Full Name
F-box/LRR-repeat protein 2
NCBI Official Synonym Full Names
F-box and leucine rich repeat protein 2
NCBI Official Symbol
FBXL2  [Similar Products]
NCBI Official Synonym Symbols
FBL2; FBL3
  [Similar Products]
NCBI Protein Information
F-box/LRR-repeat protein 2
UniProt Protein Name
F-box/LRR-repeat protein 2
UniProt Synonym Protein Names
F-box and leucine-rich repeat protein 2
UniProt Gene Name
FBXL2  [Similar Products]
UniProt Entry Name
FBXL2_HUMAN
NCBI Summary for FBXL2 (HGNC:13598)
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Comments for FBXL2 (HGNC:13598)
FBXL2: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.

Protein type: Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: cytoplasm; membrane; SCF ubiquitin ligase complex

Molecular Function: protein binding; protein phosphatase binding; ubiquitin-protein ligase activity

Biological Process: protein modification process; protein ubiquitination; proteolysis; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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