• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

FCN3 recombinant protein :: Ficolin 3 (FCN3) Recombinant Protein

Scan QR to view Datasheet
Catalog # MBS2009080 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $115 +1 FREE 8GB USB
  0.05 mg  /  $205 +1 FREE 8GB USB
  0.1 mg  /  $295 +1 FREE 8GB USB
  0.2 mg  /  $370 +1 FREE 8GB USB
  0.5 mg  /  $710 +1 FREE 8GB USB
  1 mg  /  $1,050 +1 FREE 8GB USB
Product Name

Ficolin 3 (FCN3), Recombinant Protein

Popular Item
Also Known As

Recombinant Ficolin 3 (FCN3)

Matching Pairs
Matching Pairs
APC-CY7 Conjugated Antibody: Ficolin 3 (FCN3) (MBS2060432)
Immunogen: Ficolin 3 (FCN3) (MBS2009080)
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (27695601..27701315, complement). Location: 1p36.11
OMIM
604973
3D Structure
ModBase 3D Structure for O75636
Host
E. coli
Species Reactivity
Homo sapiens (Human)
Purity/Purification
>97%
Form/Format
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
Concentration
200ug/mL (lot specific)
Source
Prokaryotic expression
Residues
Glu34~Met297
Tags
N-terminal His-Tag
Tissue Specificity
Liver, Lung, Heart, Brain, Kidney
Subcellular Location
Secreted
Traits
Freeze-dried powder
Predicted isoelectric point
6.3
Predicted Molecular Mass
30.2kDa
Accurate Molecular Mass
31kDa as determined by SDS-PAGE reducing conditions
Usage
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of FCN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for FCN3 recombinant protein
Positive Control, Immunogen, SDS-PAGE, WB.

(May be suitable for use in other assays to be determined by the end user.)

Sequence Information of FCN3 recombinant protein
FCN3 recombinant protein Sequence Information image
NCBI/Uniprot data below describe general gene information for FCN3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ficolin-3 isoform 1
NCBI Official Synonym Full Names
ficolin (collagen/fibrinogen domain containing) 3
NCBI Official Symbol
NCBI Official Synonym Symbols
FCNH; HAKA1
  [Similar Products]
NCBI Protein Information
ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
UniProt Protein Name
Ficolin-3
UniProt Synonym Protein Names
Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Hakata antigen
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
FCNH; HAKA1  [Similar Products]
UniProt Entry Name
FCN3_HUMAN
NCBI Summary for FCN3
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for FCN3
FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: collagen; extracellular region

Molecular Function: protein binding; carbohydrate binding; antigen binding

Biological Process: negative regulation of virion penetration into host cell; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; defense response to virus; complement activation

Disease: Immunodeficiency Due To Ficolin 3 Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with FCN3 recombinant protein
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000