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FCRL3 recombinant protein :: Fc receptor-like protein 3 (FCRL3) Recombinant Protein

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Catalog # MBS1288578
Unit / Price
  0.05 mg (E-Coli)  /  $980 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,045 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,170 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,315 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,415 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,420 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,450 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,485 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,600 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,065 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,125 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,140 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,435 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,795 +3 FREE 8GB USB
FCRL3 recombinant protein
Product Name

Fc receptor-like protein 3 (FCRL3), Recombinant Protein

Full Product Name

Recombinant Human Fc receptor-like protein 3 (FCRL3), partial

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
18-573. Partial, provide the complete extracellular domain.
Sequence
GVAPKAVLLL NPPWSTAFKG EKVALICSSI SHSLAQGDTY WYHDEKLLKI KHDKIQITEP GNYQCKTRGS SLSDAVHVEF SPDWLILQAL HPVFEGDNVI LRCQGKDNKN THQKVYYKDG KQLPNSYNLE KITVNSVSRD NSKYHCTAYR KFYILDIEVT SKPLNIQVQE LFLHPVLRAS SSTPIEGSPM TLTCETQLSP QRPDVQLQFS LFRDSQTLGL GWSRSPRLQI PAMWTEDSGS YWCEVETVTH SIKKRSLRSQ IRVQRVPVSN VNLEIRPTGG QLIEGENMVL ICSVAQGSGT VTFSWHKEGR VRSLGRKTQR SLLAELHVLT VKESDAGRYY CAADNVHSPI LSTWIRVTVR IPVSHPVLTF RAPRAHTVVG DLLELHCESL RGSPPILYRF YHEDVTLGNS SAPSGGGASF NLSLTAEHSG NYSCDADNGL GAQHSHGVSL RVTVPVSRPV LTLRAPGAQA VVGDLLELHC ESLRGSFPIL YWFYHEDDTL GNISAHSGGG ASFNLSLTTE HSGNYSCEAD NGLGAQHSKV VTLNVTGTSR NRTGLT
OMIM
180300
3D Structure
ModBase 3D Structure for Q96P31
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of FCRL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FCRL3 recombinant protein
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
NCBI/Uniprot data below describe general gene information for FCRL3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,921 Da
NCBI Official Full Name
Fc receptor-like protein 3 isoform 3
NCBI Official Synonym Full Names
Fc receptor like 3
NCBI Official Symbol
FCRL3  [Similar Products]
NCBI Official Synonym Symbols
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
  [Similar Products]
NCBI Protein Information
Fc receptor-like protein 3
UniProt Protein Name
Fc receptor-like protein 3
UniProt Synonym Protein Names
Fc receptor homolog 3Curated; FcRH3Curated; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c
Protein Family
UniProt Gene Name
FCRL3  [Similar Products]
UniProt Synonym Gene Names
FcR-like protein 3Curated; FcRL3Curated; FcRH3Curated; hIFGP3  [Similar Products]
NCBI Summary for FCRL3
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Comments for FCRL3
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withFCRL3 recombinant protein
 Reference Product  PubMed Publications
 ZAP70 recombinant protein  >1 publications with FCRL3 and ZAP70
Pathways associated with FCRL3 recombinant protein
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