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FGF-10 recombinant protein

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Catalog # MBS695834
Unit / Price
  0.005 mg  /  $125 +1 FREE 8GB USB
  0.025 mg  /  $195 +1 FREE 8GB USB
  0.1 mg  /  $505 +1 FREE 8GB USB
  0.5 mg  /  $1,410 +1 FREE 8GB USB
  1 mg  /  $2,320 +2 FREE 8GB USB
Testing Data
Product Name

FGF-10, Recombinant Protein

Popular Item
Full Product Name

Human FGF-10

Product Synonym Names
Fibroblast Growth Factor-10, FGFA, Keratinocyte growth factor-2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MLGQDMVSP EATNSSSSS FSSPSSAGR HVRSYNHLQ GDVRWRKLF SFTKYFLKI EKNGKVSGT KKENCPYSI LEITSVEIG VVAVKAINS NYYLAMNKK GKLYGSKEF NNDCKLKER IEENGYNTY ASFNWQHNG RQMYVALNG KGAPRRGQK TRRKNTSAH FLPMVVHS
OMIM
phenotype 602115
3D Structure
ModBase 3D Structure for O15520
Purity/Purification
>= 95% by SDS-PAGE and HPLC analyses
Form/Format
Sterile filtered through a 0.2 micron filter. Lyophilized fron 5mM Sodium Phosphate pH 7.4 + 80 mM NaCl
Authenticity
Verified by N-terminal and Mass Spectrometry analyses (when applicable)
Endotoxin
Endotoxin level is <0.1 ng/ug of protein (<1EU/ug)
Protein Content
Verified by UV Spectroscopy and/or SDS-PAGE gel.
Biological Activity
Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED50 is <= 0.5 ng/ml corresponding to a specific activity of >= 2 x 106 units/mg
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in 5mM Sodium Phosphate, pH 7.4 to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
Country of Origin
USA
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of FGF-10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FGF-10 recombinant protein
FGF-10 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-10 is most related to KGF/FGF-7 and is expressed during the development and preferentially in adult lungs. It signals through the FGFR 2b. Recombinant human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.

FGF-10 recombinant protein Testing Data image
NCBI/Uniprot data below describe general gene information for FGF-10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Fibroblast growth factor 10
NCBI Official Synonym Full Names
fibroblast growth factor 10
NCBI Official Symbol
FGF10  [Similar Products]
NCBI Protein Information
fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria
UniProt Protein Name
Fibroblast growth factor 10
UniProt Synonym Protein Names
Keratinocyte growth factor 2
UniProt Gene Name
FGF10  [Similar Products]
UniProt Synonym Gene Names
FGF-10  [Similar Products]
UniProt Entry Name
FGF10_HUMAN
NCBI Summary for FGF-10
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
UniProt Comments for FGF-10
FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: extracellular matrix; extracellular space; cell surface; extracellular region; plasma membrane; nucleus

Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; chemoattractant activity; fibroblast growth factor receptor binding

Biological Process: salivary gland development; nerve growth factor receptor signaling pathway; somatic stem cell maintenance; activation of MAPK activity; urothelial cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of transcription, DNA-dependent; muscle cell fate commitment; response to lipopolysaccharide; regulation of saliva secretion; embryonic pattern specification; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; epithelial cell proliferation; positive regulation of fibroblast proliferation; positive chemotaxis; embryonic digestive tract morphogenesis; induction of an organ; mesonephros development; embryonic genitalia morphogenesis; spleen development; positive regulation of keratinocyte migration; fibroblast growth factor receptor signaling pathway; positive regulation of DNA repair; positive regulation of urothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; branching morphogenesis of a tube; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; metanephros development; positive regulation of epithelial cell proliferation; wound healing; radial glial cell differentiation; positive regulation of mitotic cell cycle; response to estradiol stimulus; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; negative regulation of cell proliferation; establishment of mitotic spindle orientation; positive regulation of MAPKKK cascade; tissue regeneration; positive regulation of lymphocyte proliferation; pancreas development; male genitalia morphogenesis; thyroid gland development; lacrimal gland development; angiogenesis; otic vesicle formation; female genitalia morphogenesis; positive regulation of Notch signaling pathway; epidermal growth factor receptor signaling pathway; hair follicle morphogenesis; phosphoinositide-mediated signaling; thymus development; keratinocyte proliferation; regulation of activin receptor signaling pathway; embryonic camera-type eye development; odontogenesis of dentine-containing teeth; limb bud formation; positive regulation of ATPase activity; pituitary gland development; actin cytoskeleton reorganization; white fat cell differentiation; insulin receptor signaling pathway; innate immune response; blood vessel remodeling; positive regulation of Ras protein signal transduction; positive regulation of DNA replication; regulation of smoothened signaling pathway

Disease: Lacrimoauriculodentodigital Syndrome; Aplasia Of Lacrimal And Salivary Glands
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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