NP_001998.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
fibroblast growth factor 4
NCBI Official Synonym Full Names
fibroblast growth factor 4
NCBI Official Synonym Symbols
HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4 [Similar Products]
NCBI Protein Information
fibroblast growth factor 4; FGF-4; HSTF-1; oncogene HST; OTTHUMP00000237541; kaposi sarcoma oncogene; transforming protein KS3; heparin-binding growth factor 4; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; fibroblast growth factor 4 splice isoform; human stomach cancer, transforming factor from FGF-related oncogene
UniProt Protein Name
Fibroblast growth factor 4
UniProt Synonym Protein Names
Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3
UniProt Synonym Gene Names
UniProt Entry Name
FGF4_HUMAN
NCBI Summary for FGF4
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq]
UniProt Comments for FGF4
Function: Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity.
Subcellular location: Secreted
Potential.
Sequence similarities: Belongs to the heparin-binding growth factors family.
Research Articles on FGF4
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Products associated with FGF4 active protein
Pathways associated with FGF4 active protein
Diseases associated with FGF4 active protein
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>153 publications with FGF4 and Neoplasms |
Carcinoma Antibodies |
>91 publications with FGF4 and Carcinoma |
Carcinoma, Embryonal Antibodies |
>36 publications with FGF4 and Carcinoma, Embryonal |
Breast Neoplasms Antibodies |
>34 publications with FGF4 and Breast Neoplasms |
Limb Deformities, Congenital Antibodies |
>31 publications with FGF4 and Limb Deformities, Congenital |
Head and Neck Neoplasms Antibodies |
>29 publications with FGF4 and Head and Neck Neoplasms |
Carcinoma, Squamous Cell Antibodies |
>26 publications with FGF4 and Carcinoma, Squamous Cell |
Cell Transformation, Neoplastic Antibodies |
>25 publications with FGF4 and Cell Transformation, Neoplastic |
Neoplasm Metastasis Antibodies |
>19 publications with FGF4 and Neoplasm Metastasis |
Neovascularization, Pathologic Antibodies |
>17 publications with FGF4 and Neovascularization, Pathologic |
Organs/Tissues associated with FGF4 active protein
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