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FGF6 recombinant protein

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Catalog # MBS539444
Unit / Price
  0.025 mg  /  $310 +1 FREE 8GB USB
FGF6 recombinant protein
Product Name

FGF6, Recombinant Protein

Also Known As

FGF6 protein

Product Synonym Names
Fibroblast Growth Factor-6 protein; FGF 6; FGF 6 protein; FGF-6; HST-2 protein; HBGF-6 protein; FGF6; FGF-6 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
208
Sequence
Region of FGF6 protein correspond ing to amino acids MGTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI.
OMIM
134921
3D Structure
ModBase 3D Structure for P10767
Host
Human
Purity/Purification
> 95% pure
Form/Format
Supplied as a lyophilized powder.
Protein Type
Recombinant
Biological Significance
FGF6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4.
Bioactivity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6 units/mg.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of FGF6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FGF6 recombinant protein
Purified recombinant Human FGF6 protein
Applications Tested/Suitable for FGF6 recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for FGF6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18.7 kDa
NCBI Official Full Name
fibroblast growth factor 6
NCBI Official Synonym Full Names
fibroblast growth factor 6
NCBI Official Symbol
NCBI Official Synonym Symbols
HST2; HBGF-6
  [Similar Products]
NCBI Protein Information
fibroblast growth factor 6
UniProt Protein Name
Fibroblast growth factor 6
UniProt Synonym Protein Names
Heparin secretory-transforming protein 2; HST-2; HSTF-2; Heparin-binding growth factor 6; HBGF-6
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HST2; HSTF2; FGF-6; HST-2; HSTF-2; HBGF-6  [Similar Products]
UniProt Entry Name
FGF6_HUMAN
NCBI Summary for FGF6
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]
UniProt Comments for FGF6
FGF6: Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Belongs to the heparin-binding growth factors family.

Protein type: Oncoprotein; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular space; extracellular region; sarcolemma

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; signal transduction; myoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; angiogenesis; cartilage condensation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with FGF6 recombinant protein
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