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FGFR1OP cdna clone

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Catalog # MBS1269232
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
FGFR1OP cdna clone
Product Name

FGFR1OP, cDNA Clone

Full Product Name

FGFR1OP cDNA Clone

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggcga cggcggccgc agtggtggcc gaggaggaca cggagctgcg ggacctgctg gtgcagacgc tggagaacag cggggtcctg aaccgcatca aggctgaact ccgagcagct gtgtttttag cactagagga gcaagaaaaa gtagagaaca aaactccttt agttaatgag agcctgagaa agtttttaaa taccaaagac ggtcgtttag tggctagtct tgttgcagaa tttcttcagt tttttaacct tgactttact ttggctgttt ttcaacctga aactagcaca ctgcaaggtc tcgaaggtcg agagaattta gcccgagatt taggtataat tgaagcagaa ggtactgtgg gtggaccctt attattagaa gtgatcaggc gctgtcaaca gaaagaaaaa gggccaacca ctggggaagg tgcacttgat ctatctgatg tacattctcc accaaagtca ccagagggaa aaacaagtgc acagacaaca ccaagtaaga aggccaatga tgaggccaat cagagtgata caagtgtctc cttgtcagaa cccaagagca aaagcagcct tcacttactg tcccatgaaa caaaaattgg atcttttcta agcaacagaa ctttagatgg caaagacaaa gctggccttt gtccagatga agatgatatg gaaggagatt ctttctttga tgatcccatt cctaagccag agaaaactta cggtttgagg aatgaaccta ggaagcaagc aggaagtctg gcctcgctct cggatgcacc ccccttaaaa agtggactca gctccctggc gggagcccct tctttaaaag actctgagag taaaagggga aatacagttt tgaaagatct gaaattgatc agtgataaaa ttggatcact tggattagga actggagaag atgatgacta tgttgatgat tttaatagta ccagccatcg ctcagagaaa agtgagataa gtattggtga agagatagaa gaagaccttt ctgtggaaat agatgacatc aataccagtg ataagcttga tgacctcaca caagatctga ctgtatccca gctcagtgat gttgcggatt atctggaaga tgttgcatag
OMIM
605392
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of FGFR1OP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FGFR1OP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,106 Da
NCBI Official Full Name
Homo sapiens FGFR1 oncogene partner, mRNA
NCBI Official Synonym Full Names
FGFR1 oncogene partner
NCBI Official Symbol
FGFR1OP  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
FGFR1 oncogene partner
UniProt Protein Name
FGFR1 oncogene partner
Protein Family
UniProt Gene Name
FGFR1OP  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
FR1OP_HUMAN
NCBI Summary for FGFR1OP
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
UniProt Comments for FGFR1OP
FOP: Required for anchoring microtubules to the centrosomes. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the FGFR1OP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: centrosome; cytosol; nucleus; perinuclear region of cytoplasm

Molecular Function: protein binding; protein homodimerization activity; protein kinase binding; protein tyrosine kinase inhibitor activity; protein-tyrosine kinase activity

Biological Process: G2/M transition of mitotic cell cycle; negative regulation of protein kinase activity; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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