NP_001139247.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
NCBI Official Synonym Full Names
FK506 binding protein 5
NCBI Official Synonym Symbols
P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10 [Similar Products]
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP5; FKBP-5; FKBP-51; rotamase; 51 kDa FKBP; FF1 antigen; PPIase FKBP5; HSP90-binding immunophilin; T-cell FK506-binding protein; androgen-regulated protein 6; 51 kDa FK506-binding protein 5; peptidylprolyl cis-trans isomerase; 54 kDa progesterone receptor-associated immunophilin
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP5
UniProt Synonym Protein Names
51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase
UniProt Synonym Gene Names
AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54 [Similar Products]
UniProt Entry Name
FKBP5_HUMAN
NCBI Summary for FKBP5
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
UniProt Comments for FKBP5
FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin.
Protein type: Chaperone; EC 5.2.1.8; Isomerase
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane
Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; heat shock protein binding
Biological Process: protein peptidyl-prolyl isomerization; protein folding
Disease: Major Depressive Disorder
Research Articles on FKBP5
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Products associated with FKBP5 recombinant protein
Pathways associated with FKBP5 recombinant protein
Diseases associated with FKBP5 recombinant protein
Organs/Tissues associated with FKBP5 recombinant protein
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