NP_036313.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP8
NCBI Official Synonym Full Names
FK506 binding protein 8, 38kDa
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP8; FKBP-8; FKBP-38; hFKBP38; rotamase; 38 kDa FKBP; PPIase FKBP8; 38 kDa FK506-binding protein; FK506-binding protein 8 (38kD)
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP8
UniProt Synonym Protein Names
38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase
UniProt Synonym Gene Names
UniProt Entry Name
FKBP8_HUMAN
NCBI Summary for FKBP8
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
UniProt Comments for FKBP8
FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 5.2.1.8; Chaperone; Mitochondrial; Membrane protein, integral; Isomerase
Chromosomal Location of Human Ortholog: 19p12
Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial membrane; integral to endoplasmic reticulum membrane
Molecular Function: identical protein binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; metal ion binding
Biological Process: smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; viral reproduction; apoptosis; regulation of gene expression; multicellular organism growth; cell fate specification; dorsoventral neural tube patterning; positive regulation of BMP signaling pathway; negative regulation of apoptosis
Research Articles on FKBP8
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Products associated with FKBP8 recombinant protein
Pathways associated with FKBP8 recombinant protein
Diseases associated with FKBP8 recombinant protein
Organs/Tissues associated with FKBP8 recombinant protein
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