CAA81393.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,378 Da
NCBI Official Full Name
FLT3 receptor tyrosine kinase
NCBI Official Synonym Full Names
fms-related tyrosine kinase 3
NCBI Protein Information
receptor-type tyrosine-protein kinase FLT3; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; stem cell tyrosine kinase 1
UniProt Protein Name
Receptor-type tyrosine-protein kinase FLT3
UniProt Synonym Protein Names
FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135
UniProt Synonym Gene Names
UniProt Entry Name
FLT3_HUMAN
NCBI Summary for Flt3
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
UniProt Comments for Flt3
FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412.
Protein type: Protein kinase, TK; Kinase, protein; Oncoprotein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; PDGFR family
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: protein complex; integral to plasma membrane; endoplasmic reticulum lumen; nucleus; cytosol; external side of plasma membrane
Molecular Function: vascular endothelial growth factor receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; protein complex binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; glucocorticoid receptor binding
Biological Process: negative regulation of B cell differentiation; lymphocyte proliferation; pro-B cell differentiation; organ regeneration; peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; response to organic nitrogen; regulation of apoptosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; myeloid progenitor cell differentiation; positive regulation of MAPKKK cascade; B cell differentiation; positive regulation of cell proliferation; hemopoiesis; pro-T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; leukocyte homeostasis
Disease: Leukemia, Acute Lymphoblastic
Research Articles on Flt3
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Products associated with Flt3 elisa kit
Pathways associated with Flt3 elisa kit
Diseases associated with Flt3 elisa kit
Disease Name |
Pubmed Publications |
Leukemia, Myeloid, Acute Antibodies |
>1824 publications with Flt3 and Leukemia, Myeloid, Acute |
Bone Marrow Diseases Antibodies |
>310 publications with Flt3 and Bone Marrow Diseases |
Cell Transformation, Neoplastic Antibodies |
>158 publications with Flt3 and Cell Transformation, Neoplastic |
Leukemia, Promyelocytic, Acute Antibodies |
>147 publications with Flt3 and Leukemia, Promyelocytic, Acute |
Necrosis Antibodies |
>125 publications with Flt3 and Necrosis |
Neoplasms, Experimental Antibodies |
>101 publications with Flt3 and Neoplasms, Experimental |
Inflammation Antibodies |
>90 publications with Flt3 and Inflammation |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>73 publications with Flt3 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Lung Diseases Antibodies |
>48 publications with Flt3 and Lung Diseases |
Melanoma Antibodies |
>46 publications with Flt3 and Melanoma |
Organs/Tissues associated with Flt3 elisa kit
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