NP_001191431.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
fms-related tyrosine kinase 3 ligand isoform 1
NCBI Official Synonym Full Names
fms-related tyrosine kinase 3 ligand
NCBI Official Synonym Symbols
NCBI Protein Information
fms-related tyrosine kinase 3 ligand; flt3 ligand
UniProt Protein Name
Fms-related tyrosine kinase 3 ligand
UniProt Synonym Protein Names
SL cytokine
UniProt Synonym Gene Names
UniProt Entry Name
FLT3L_HUMAN
NCBI Summary for FLT3LG
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
UniProt Comments for FLT3LG
FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cytokine; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: extracellular space; membrane; integral to membrane
Molecular Function: protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding; receptor binding
Biological Process: positive regulation of natural killer cell differentiation; regulation of myeloid dendritic cell activation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; signal transduction; positive regulation of myoblast differentiation
Research Articles on FLT3LG
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Products associated with FLT3LG active protein
Pathways associated with FLT3LG active protein
Diseases associated with FLT3LG active protein
Organs/Tissues associated with FLT3LG active protein
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