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FMO3 cdna clone

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Catalog # MBS1267019
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
FMO3 cdna clone
Product Name

FMO3, cDNA Clone

Popular Item
Full Product Name

FMO3 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggaaga aagtggccat cattggagct ggtgtgagtg gcttggcctc catcaggagc tgtctggaag aggggctgga gcccacctgc tttgagaaga gcaatgacat tgggggcctg tggaaatttt cagaccatgc agaggagggc agggctagca tttacaaatc agtcttttcc aactcttcca aagagatgat gtgtttccca gacttcccat ttcccgatga cttccccaac tttatgcaca acagcaagat ccaggaatat atcattgcat ttgccaaaga aaagaacctc ctgaagtaca tacaatttaa gacatttgta tccagtgtaa ataaacatcc tgattttgca actactggcc agtgggatgt taccactgaa agggatggta aaaaagaatc ggctgtcttt gatgctgtaa tggtttgttc cggacatcat gtgtatccca acctaccaaa agagtccttt ccaggactaa accactttaa aggcaaatgc ttccacagca gggactataa agaaccaggt gtattcaatg gaaagcgtgt cctggtggtt ggcctgggga attcgggctg tgatattgcc acagaactca gccgcacagc agaacaggtc atgatcagtt ccagaagtgg ctcctgggtg atgagccggg tctgggacaa tggttatcct tgggacatgc tgctcgtcac tcgatttgga accttcctca agaacaattt accgacagcc atctctgact ggttgtacat gaagcagatg aatgcaagat tcaagcatga aaactatggc ttgatgcctt taaatggagt cctgaggaaa gagcctgtat ttaacgatga gctcccagca agcattctgt gtggcattgt gtccgtaaag cctaacgtga aggaattcac agagacctcg gccatttttg aggatgggac catatttgag ggcattgact gtgtaatctt tgcaacaggg tatagttttg cctacccctt ccttgatgag tctatcatca aaagcagaaa caatgagatc attttattta aaggagtatt tcctcctcta cttgagaagt caaccatagc agtgattggc tttgtccagt cccttggggc tgccattccc acagttgacc tccagtcccg ctgggcagca caagtaataa agggaacttg tactttgcct tctatggaag acatgatgaa tgatattaat gagaaaatgg agaaaaagcg caaatggttt ggcaaaagcg agaccataca gacagattac attgtttata tggatgaact ctcctccttc attggggcaa agcccaacat cccatggctg tttctcacag atcccaaatt ggccatggaa gtttattttg gcccttgtag tccctaccag tttaggctgg tgggcccagg gcagtggcca ggagccagaa atgccatact gacccagtgg gaccggtcgt tgaaacccat gcagacacga gtggtcggga gacttcagaa gccttgcttc tttttccatt ggctgaagct ctttgcaatt cctattctgt taatcgctgt tttccttgtg ttgacctaa
OMIM
136132
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of FMO3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FMO3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,033 Da
NCBI Official Full Name
Homo sapiens flavin containing monooxygenase 3, mRNA
NCBI Official Synonym Full Names
flavin containing monooxygenase 3
NCBI Official Symbol
NCBI Official Synonym Symbols
TMAU; FMOII; dJ127D3.1
  [Similar Products]
NCBI Protein Information
dimethylaniline monooxygenase [N-oxide-forming] 3
UniProt Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 3
UniProt Synonym Protein Names
Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase (EC:1.14.13.148)
UniProt Gene Name
UniProt Synonym Gene Names
FMO 3  [Similar Products]
UniProt Entry Name
FMO3_HUMAN
NCBI Summary for FMO3
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
UniProt Comments for FMO3
FMO3: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds. Defects in FMO3 are the cause of trimethylaminuria (TMAU); also known as fish-odor syndrome. TMAU is an inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino- trimethylamine (TMA) derived from foodstuffs. Such individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. Belongs to the FMO family.

Protein type: EC 1.14.13.148; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.8

Chromosomal Location of Human Ortholog: 1q24.3

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: flavin-containing monooxygenase activity; monooxygenase activity

Biological Process: xenobiotic metabolic process

Disease: Trimethylaminuria
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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