BC032016
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,033 Da
NCBI Official Full Name
Homo sapiens flavin containing monooxygenase 3, mRNA
NCBI Official Synonym Full Names
flavin containing monooxygenase 3
NCBI Protein Information
dimethylaniline monooxygenase [N-oxide-forming] 3
UniProt Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 3
UniProt Synonym Protein Names
Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase (EC:1.14.13.148)
UniProt Synonym Gene Names
UniProt Entry Name
FMO3_HUMAN
NCBI Summary for FMO3
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
UniProt Comments for FMO3
FMO3: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds. Defects in FMO3 are the cause of trimethylaminuria (TMAU); also known as fish-odor syndrome. TMAU is an inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino- trimethylamine (TMA) derived from foodstuffs. Such individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. Belongs to the FMO family.
Protein type: EC 1.14.13.148; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.8
Chromosomal Location of Human Ortholog: 1q24.3
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
Molecular Function: flavin-containing monooxygenase activity; monooxygenase activity
Biological Process: xenobiotic metabolic process
Disease: Trimethylaminuria
Research Articles on FMO3
Precautions
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Pathways associated with FMO3 cdna clone
Diseases associated with FMO3 cdna clone
Organs/Tissues associated with FMO3 cdna clone
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