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FMO3 recombinant protein :: Dimethylaniline monooxygenase [N-oxide-forming] 3 (FMO3) Recombinant Protein

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Catalog # MBS958701
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $955 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,005 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,240 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,365 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,410 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,480 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,550 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,795 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,140 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,325 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,390 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,460 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,580 +4 FREE 8GB USB
FMO3 recombinant protein
Product Name

Dimethylaniline monooxygenase [N-oxide-forming] 3 (FMO3), Recombinant Protein

Full Product Name

Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 3 (FMO3)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-532aa, Full Length of Mature Protein
Sequence
GKKVAIIGAG VSGLASIRSC LEEGLEPTCF EKSNDIGGLW KFSDHAEEGR ASIYKSVFSN SSKEMMCFPD FPFPDDFPNF MHNSKIQEYI IAFAKEKNLL KYIQFKTFVS SVNKHPDFAT TGQWDVTTER DGKKESAVFD AVMVCSGHHV YPNLPKESFP GLNHFKGKCF HSRDYKEPGV FNGKRVLVVG LGNSGCDIAT ELSRTAEQVM ISSRSGSWVM SRVWDNGYPW DMLLVTRFGT FLKNNLPTAI SDWLYVKQMN ARFKHENYGL MPLNGVLRKE PVFNDELPAS ILCGIVSVKP NVKEFTETSA IFEDGTIFEG IDCVIFATGY SFAYPFLDES IIKSRNNEII LFKGVFPPLL EKSTIAVIGF VQSLGAAIPT VDLQSRWAAQ VIKGTCTLPS MEDMMNDINE KMEKKRKWFG KSETIQTDYI VYMDELSSFI GAKPNIPWLF LTDPKLAMEV YFGPCSPYQF RLVGPGQWPG ARNAILTQWD RSLKPMQTRV VGRLQKPCFF FHWLKLFAIP ILLIAVFLVL T
OMIM
136132
3D Structure
ModBase 3D Structure for P31513
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FMO3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FMO3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,033 Da
NCBI Official Full Name
dimethylaniline monooxygenase
NCBI Official Synonym Full Names
flavin containing monooxygenase 3
NCBI Official Symbol
NCBI Official Synonym Symbols
TMAU; FMOII; dJ127D3.1
  [Similar Products]
NCBI Protein Information
dimethylaniline monooxygenase [N-oxide-forming] 3
UniProt Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 3
UniProt Synonym Protein Names
Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase (EC:1.14.13.148)
UniProt Gene Name
UniProt Synonym Gene Names
FMO 3  [Similar Products]
NCBI Summary for FMO3
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
UniProt Comments for FMO3
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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