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FN1 protein :: Fibronectin Protein

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Catalog # MBS135795
Unit / Price
  1 mg  /  $260 +1 FREE 8GB USB
  10 mg  /  $1,460 +1 FREE 8GB USB
FN1 protein
Product Name

Fibronectin (FN1), Protein

Also Known As

Human Fibronectin

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
2355
Chromosome Location
Chromosome: 2; NC_000002.11 (216225177..216300791, complement). Location: 2q34
OMIM
135600
3D Structure
ModBase 3D Structure for P02751
Host
Human plasma
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen liquid
Concentration
10.0 mg/ml (lot specific)
Buffer
0.1 M Tris-Cl; 0.15 M NaCl; pH 7.4
Extinction Coefficient
1.28
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Other Notes
Small volumes of FN1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FN1 protein
Prepared from fresh human plasma. Ideal reagent for tissue culture studies and protein-protein interactions. Thaw the fibronectin by placing the vial in a 37 C water bath and leaving it undisturbed until completely thawed. Do not disturb the vial at any t
Product Categories/Family for FN1 protein
NCBI/Uniprot data below describe general gene information for FN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
220,000
NCBI Official Full Name
fibronectin isoform 3 preproprotein
NCBI Official Synonym Full Names
fibronectin 1
NCBI Official Symbol
NCBI Official Synonym Symbols
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2
  [Similar Products]
NCBI Protein Information
fibronectin; cold-insoluble globulin; migration-stimulating factor
UniProt Protein Name
Fibronectin
UniProt Synonym Protein Names
Cold-insoluble globulin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
FN; FN; CIG  [Similar Products]
UniProt Entry Name
FINC_HUMAN
NCBI Summary for FN1
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for FN1
FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cell adhesion; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: extracellular matrix; extracellular space; apical plasma membrane; fibrinogen complex; extracellular region; ER-Golgi intermediate compartment; basal lamina

Molecular Function: collagen binding; heparin binding; integrin binding; protein binding; protease activator activity; protease binding

Biological Process: integrin activation; platelet activation; extracellular matrix organization and biogenesis; positive regulation of axon extension; regulation of cell shape; extracellular matrix disassembly; platelet degranulation; acute-phase response; response to wounding; calcium-independent cell-matrix adhesion; cell-substrate junction assembly; peptide cross-linking; angiogenesis; cell adhesion; blood coagulation; leukocyte migration

Disease: Glomerulopathy With Fibronectin Deposits 2; Plasma Fibronectin Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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